Influence of magnesium deficiency on concentration of calcium in soft tissue of uremic rats

Renal Failure
O InagakiY Takamitsu

Abstract

The influence of magnesium (Mg) deficiency on the concentration of calcium (Ca) in the aorta, heart, and kidney was evaluated in uremic rats. A total of 32 rats were randomly assigned to two groups: one group made uremic by the 5/6 nephrectomy method, and the other serving as sham-operated controls. Both groups were randomly assigned to two subgroups: one group given a Mg-deficient diet and the other fed a Mg-supplemented diet. After 12 weeks on the regimen, all animals were sacrificed. In Mg-supplemented uremic rats, the concentration of Ca in the aorta was higher than in Mg-supplemented control rats. The concentration of Ca in the aorta was further increased in Mg-deficient uremic rats. The concentrations of Ca in the heart and the kidney were also increased in Mg-deficient uremic rats, as compared with Mg-supplemented uremic rats. The concentration of Mg was decreased in the aorta and increased in the kidney of Mg-deficient rats. There was no significant influence of Mg deficiency on the concentration of phosphate in tissue. Results suggest that Mg deficiency in uremia may increase aortic calcification.

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Citations

Jan 4, 2007·Advances in Chronic Kidney Disease·Mohga El-Abbadi, Cecilia M Giachelli
Mar 20, 2014·Hemodialysis International·Periklis DousdampanisCostas Fourtounas
Jul 18, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lin LiKamyar Kalantar-Zadeh
Oct 22, 2015·The Journal of Pharmacology and Experimental Therapeutics·Jason G E ZeltMichael A Adams

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