Influence of malnutrition on the prevalence of bacterial translocation and spontaneous bacterial peritonitis in experimental cirrhosis in rats

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
F CasafontF P Romero

Abstract

Bacterial translocation (BT) has been involved in the pathogenesis of spontaneous bacterial peritonitis (SBP) in experimental cirrhosis. Because malnutrition is a common feature in cirrhosis, the aim of this study was to evaluate the effect of nutrition on BT and SBP. We induced cirrhosis in 44 Sprague-Dawley rats by administration of oral CCl4, and, afterward, 26 animals were maintained with dietary restriction. Cultures of mesenteric lymph nodes (MLN), peripheral and portal blood, liver, and spleen were performed. SBP occurred in 48% of the rats with ascites, this being more frequent in the malnourished animals (80%) than in control rats (29%). BT appeared in all the rats with SBP (100%) but only in 57% without it. In the malnourished animals, the BT rate was 95%, while it was 30% in the control group. These results suggest that malnutrition increases the BT rate and the risk of developing SBP in experimental cirrhosis, and that BT is frequent in cirrhosis and may play a role in the development of SBP.

Citations

Apr 13, 1999·Nutrition·B A Mizock
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PardoM A Gassull
Dec 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ya-Wen ChuangCheng-Hsu Chen
Dec 17, 1998·Journal of Clinical Gastroenterology·S D MalnickD Geltner
Dec 3, 2010·Seminars in Dialysis·Ron Zanger
Feb 13, 2008·BMC Gastroenterology·Sedef KuranBurhan Sahin
Sep 3, 2013·Journal of Hepatology·Reiner WiestMarkus Geuking
Jan 19, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Zhong-Wen WuLan-Juan Li
Nov 29, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Francesco CorradiMiquel Navasa
Nov 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zora TeltschikJan Wehkamp
Feb 6, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Helena A S GoldaniThemis R Silveira
Dec 15, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Chien-Hao HuangCheng-Tang Chiu
Sep 22, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Armando Guerra-RuizFernando Pons-Romero
Mar 13, 2003·World Journal of Gastroenterology : WJG·Shun-Cai ZhangWu-Nan Zhu
May 29, 2018·Expert Review of Gastroenterology & Hepatology·Francesca Romana PonzianiMaurizio Pompili
Oct 16, 1999·The American Journal of Gastroenterology·L Blendis, F Wong
Jan 1, 2001·Living Reviews in Relativity·Sean M Carroll
Jan 29, 2016·World Journal of Gastroenterology : WJG·Mercedes MárquezJosé Antonio Girón-González
Mar 28, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasunari HiramineAkio Ido
May 22, 2018·Frontiers in Physiology·Yang LiuYunwei Wei
Oct 31, 2014·World Journal of Gastroenterology : WJG·Emilio González-ReimersGeraldine Quintero-Platt
Mar 31, 2021·International Journal of Clinical Practice·Danyang LiuJun Ai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.