Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse.

Genetics
G L Wolff

Abstract

The results of extensive breeding experiments indicate that the phenotypic differentiation of embryos carrying the viable yellow, A( vy), or mottled, a(m), mutations is influenced to a major extent by the agouti locus genotype and the strain genome of the dam. The A(vy)/a and a(m)/a genotypes are each expressed in a spectrum of coat color phenotypes. These can be grouped into two classes, mottled and pseudoagouti.-In a reciprocal cross of C57BL/6JNIcrWf and AM/Wf-a(m)/a(m) mice, 29.5% of the offspring of C57BL/6 dams were of the pseudoagouti phenotype, whereas no pseudoagouti offspring were produced by AM strain dams.-Mottled yellow A(vy)/a mice become obese and tumor formation is enhanced in these mice in comparison with the lean pseudoagouti A(vy)/a siblings.-In two different reciprocal crosses using four different inbred strains, the proportion of pseudoagouti A(vy)/a offspring differed according to the strain of the dam. Regardless of strain, mottled yellow A( vy)/a dams produced significantly fewer pseudoagouti A( vy)/a offspring than did black a/a dams.-The data suggest that metabolic differentiation of A(vy)/a zygotes into phenotypic classes with different susceptibilities to obesity and tumor formation is influenced to ...Continue Reading

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