Influence of mechanical stress on palmoplantar erythrodysesthesia--a case report

Oncology Research and Treatment
Sora JungJürgen Lademann

Abstract

Cutaneous adverse events can have an important negative influence on quality of life and compliance in affected patients. Palmoplantar erythrodysesthesia (PPE; hand-foot syndrome) is a cutaneous toxicity associated with chemotherapeutic treatment, which necessitates treatment interruption or dose reduction in severe cases. This case report of pegylated liposomal doxorubicin-induced PPE shows the influence of mechanical stress on the development of skin lesions in various locations and the importance of patient education and compliance. We present the case of a 43-year-old female patient diagnosed with ovarian cancer and having undergone surgical and chemotherapeutic treatment. The development of extensive grade 3 PPE affecting numerous areas of the body particularly exposed to mechanical pressure necessitated dermatological treatment. The combination of local application of an antioxidant-containing ointment and the patient's compliance made it possible to continue chemotherapy without interruption or dose reduction. The development of PPE often limits the use of chemotherapeutic agents, and this case report can provide a possible therapeutic and preventive strategy for affected patients.

Citations

Mar 11, 2017·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J LademannL Zastrow
Apr 28, 2016·Journal of Biomedical Optics·Mao-Dong HuangSora Jung
Jun 28, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S JungJ Lademann
Dec 29, 2020·The Journal of International Medical Research·Chenxu NiFuming Shen

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