PMID: 7540081Feb 1, 1995Paper

Influence of melatonin on bovine pulmonary vascular and bronchial airway smooth muscle tone

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
L B Weekley

Abstract

The influence of melatonin on tension of isolated bovine pulmonary vascular and bronchial smooth muscle rings were examined in these experiments. Melatonin caused a dose-dependent relaxation of precontracted (30 mM KCl) pulmonary artery and vein, although the effect is greater in arterial smooth muscle. This relaxant response was blocked by preincubating vessels with antagonists of vasoactive intestinal peptide or Substance P. In bronchial smooth muscle, melatonin caused a small contractile response. These experiments demonstrate that in response to melatonin the pulmonary vasculature relaxes, while in airway smooth muscle the reverse, constriction, occurs. It is hypothesized that nocturnal exaggeration of asthma may, in part, be due to changes in circulating levels of melatonin.

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Citations

Sep 19, 2003·The Journal of Allergy and Clinical Immunology·E Rand SutherlandRichard J Martin
Dec 22, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P E Silkoff, R J Martin
Aug 17, 2006·Fiziologiia cheloveka·E V Evsiukova
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·E Rand SutherlandMonica Kraft
Aug 13, 2004·American Journal of Respiratory and Critical Care Medicine·Francineide L CamposPedro F C de Bruin
Aug 27, 2014·Clinics in Chest Medicine·Wajahat H KhanCarolyn M D'Ambrosio
Aug 6, 2014·International Journal of Molecular Sciences·Lucia MarsegliaEloisa Gitto
Nov 7, 2016·Italian Journal of Pediatrics·Gabriella D'AngeloEloisa Gitto
Jun 1, 1996·Pediatric Annals·M S Schamberger
Oct 1, 2005·Respiration; International Review of Thoracic Diseases·Selma Arzu VardarKadir Kaymak
Apr 30, 1999·Transplantation·K V KumarK S Ratnakar
Jul 30, 2019·Frontiers in Endocrinology·Felipe A BeñaldoMaría Serón-Ferré
Dec 2, 2020·Biomedical Journal·Fahimeh Ghotbizadeh VahdaniFarzaneh Nazari

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