Influence of menthol and pressure-sensitive adhesives on the in vivo performance of membrane-moderated transdermal therapeutic system of nicardipine hydrochloride in human volunteers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Y S R KrishnaiahP Bhaskar

Abstract

A membrane-moderated transdermal therapeutic system of nicardipine hydrochloride was developed using 2% w/w hydroxypropylcellulose (HPC) gel as a reservoir system containing 5% w/w of menthol as a penetration enhancer. The permeability flux of nicardipine hydrochloride through the ethylene vinyl acetate (EVA) copolymer membrane was found to increase with an increase in vinyl acetate content in the copolymer. The effect of various pressure-sensitive adhesives (MA-31, MA-38 or TACKWHITE A 4MED on the permeability of nicardipine hydrochloride through EVA 2825 membrane (28% w/w vinyl acetate) or EVA 2825 membrane/skin composite was also studied. The results showed that nicardipine hydrochloride permeability through EVA 2825 membrane coated with TACKWHITE A 4MED/skin composite was higher than that coated with MA-31 or MA-38. Thus, a new transdermal therapeutic system for nicardipine hydrochloride was formulated using EVA 2825 membrane coated with a pressure-sensitive adhesive TACKWHITE A 4MED, and 2% w/w HPC gel as reservoir containing 5% w/w of menthol as a penetration enhancer. In vivo studies in healthy human volunteers indicated that the TTS of nicardipine hydrochloride, designed in the present study, provided steady-state plasm...Continue Reading

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Citations

Dec 4, 2013·International Journal of Biological Macromolecules·Abdul AhadAsgar Ali
Oct 6, 2012·Therapeutic Delivery·Sevgi Güngör, Yildiz Ozsoy
Sep 27, 2008·Pharmaceutical Development and Technology·Yellela S R KrishnaiahVemulapalli Satyanarayana
Mar 27, 2013·Expert Opinion on Drug Delivery·Abdul AhadKanchan Kohli
Jun 16, 2010·Drug Development and Industrial Pharmacy·Pao-Chu WuYi-Hung Tsai
Dec 7, 2007·Drug Discovery Today·Mohammed AqilAsgar Ali
Jan 18, 2005·International Journal of Pharmaceutics·Chomchan AmnuaikitToshikiro Kimura
Jul 5, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y S R KrishnaiahV Satyanarayana
Mar 25, 2011·Pharmaceutical Development and Technology·Yellela S R Krishnaiah, Aly Nada
Aug 23, 2005·Skin Pharmacology and Physiology·Y S R KrishnaiahS M Al-Saidan

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