Influence of metoprolol on heart rate variability in survivors of remote myocardial infarction

The American Journal of Cardiology
E C KeeleyL D Hillis

Abstract

We assessed the influence of metoprolol on heart rate variability in survivors of remote myocardial infarction. In 43 survivors of myocardial infarction 12 to 18 months previously (26 men and 17 women, aged 38 to 69 years), two 24-hour ambulatory electrocardiograms were recorded 2 weeks apart. In patients in group A (n=28), who had taken metoprolol for the previous year, the drug was discontinued for 2 weeks, after which the first recording was done. The second recording was done 2 weeks after metoprolol was resumed. In patients in group B (n=15), who had not taken metoprolol for the previous year, it continued to be withheld, and two 24-hour recordings were done 2 weeks apart. In group A, metoprolol increased the time domain variables indicative of enhanced vagal tone; root-mean-square successive difference in normal RR (NN) intervals was 20 +/- 11 ms (mean +/- SD) without and 24 +/- 9 ms with metoprolol (p<0.05), and the proportion of NN that differ by >50 ms (pNN50%) was 3.6 +/- 6.0 without and 5.5 +/- 6.0 with metoprolol (p<0.05). In the frequency domain, the logarithms of the 24-hour very low frequency and the 24-hour high-frequency power (reflecting parasympathetic activity) were increased (5.12 +/- 1.03 and 4.48 +/- 1.51...Continue Reading

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Citations

Jun 7, 2002·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Juha S Perkiömäki
Jun 7, 2002·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Mustafa RidhaRobert J Myerburg
Aug 31, 2001·Journal of the American College of Cardiology·W J KopD S Krantz
Nov 13, 2012·Neurobiology of Aging·Aisha S S Meel-van den AbeelenJurgen A H R Claassen
Jun 12, 2004·Current Problems in Cardiology·Gregory EngelPaul J Wang
May 29, 2007·Journal of Electrocardiology·Andrew D MichaelsElizabeth D Kennard
Jun 11, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael J LoguidiceEllen C Keeley
Apr 16, 2003·Annals of Medicine·Saila VikmanHeikki V Huikuri

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