PMID: 9557160Apr 29, 1998Paper

Influence of microbial stimulation on hypergammaglobulinemia and autoantibody production in pristane-induced lupus

Clinical Immunology and Immunopathology
K J HamiltonWestley H Reeves

Abstract

Pristane induces a lupus-like syndrome characterized by autoantibody production and glomerulonephritis in nonautoimmune strains of mice. Although it has been suggested that this syndrome results from nonspecific immune activation, there is little evidence so far that B cells are activated nonspecifically by pristane or that this promotes autoimmunity. In this study, we examined whether polyclonal hypergammaglobulinemia occurs in pristane-induced lupus, and its relationship to the production of anti-DNA, nRNP/Sm, and Su autoantibodies. In conventionally housed mice, there was a marked increase in total IgM and IgG3 2 weeks after i.p. pristane injection, followed by increased IgG1, IgG2a, and IgG2b levels. IgM levels were higher in pristane-treated specific pathogen-free (SPF) mice than in conventionally housed mice, whereas IgG and IgA levels were reduced. Pristane induced anti-nRNP/Sm and Su autoantibodies in SPF mice, but their onset was delayed and levels were lower than those in conventionally housed mice. There was no consistent relationship between total IgG1, 2a, and 2b hypergammaglobulinemia and production of anti-nRNP/Sm and Su autoantibodies. Moreover, the total Ig levels were similar in the anti-nRNP/Sm-positive and -...Continue Reading

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Citations

Aug 2, 2003·Journal of Autoimmunity·Minoru SatohWestley H Reeves
Dec 3, 2008·The Journal of Experimental Medicine·Pui Y LeeWestley H Reeves
Mar 15, 2008·The Journal of Clinical Investigation·Donna L ThibaultPaul J Utz
Feb 24, 2007·Environmental Health : a Global Access Science Source·James DahlgrenRaphael Warshaw
Sep 30, 1999·Environmental Health Perspectives·V M ShaheenW H Reeves
Sep 5, 2002·Arthritis and Rheumatism·Hideo YoshidaWestley H Reeves
Jun 18, 2010·Vaccine·Erlend HaugarvollErling O Koppang
Dec 5, 2015·Frontiers in Immunology·Borja SánchezAbelardo Margolles
Jan 11, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Akiei MizutaniMinoru Satoh
Jun 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yoshiki KurodaMinoru Satoh
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Nov 12, 2002·Environmental Health Perspectives·Jesper Bo Nielsen, Per Hultman
May 9, 2000·Clinical and Diagnostic Laboratory Immunology·J O NaimW H Reeves
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dina C NacionalesWestley H Reeves
Apr 9, 2020·Frontiers in Immunology·Leila AbdelhamidXin M Luo
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SatohW H Reeves
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erling O KoppangMinoru Satoh
Sep 8, 2017·Clinical Rheumatology·Eduarda Correa FreitasOdirlei André Monticielo
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lorenza FrisoniRoberto Caricchio
Jan 6, 2000·Seminars in Arthritis and Rheumatism·R H Scofield, J A James

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