Influence of microplastics on the toxicity of the pharmaceuticals procainamide and doxycycline on the marine microalgae Tetraselmis chuii

Aquatic Toxicology
Joana C PrataLúcia Guilhermino

Abstract

Microplastics and pharmaceuticals are considered ubiquitous and emergent pollutants of high concern but the knowledge on their effects on primary producers is still limited, especially those caused by mixtures. Thus, the goal of the present study was to investigate if the presence of microplastics (1-5 μm diameter) influences the toxicity of the pharmaceuticals procainamide and doxycycline to the marine microalga Tetraselmis chuii. Bioassays (96 h) to investigate the toxicity of those substances individually and in mixtures (i.e. microplastics-procainamide mixtures and microplastics-doxycycline mixtures) were carried out. Effect criteria were the average specific growth rate (growth rate) and chlorophyll a concentration (chlorophyll). EC10, EC20 and EC50 were determined. Microplastics alone had no significant effects on growth rate up to 41.5 mg/l, whereas chlorophyll was significantly reduced at 0.9 and 2.1 mg/l of microplastics, but not at higher concentrations. The 96 h EC50 (growth rate and chlorophyll, respectively) determined for the other bioassays were: 104 and 143 mg/l for procainamide alone; 125 and 31 mg/l for procainamide in the presence of microplastics; 22 and 14 mg/l for doxycycline alone; 11 and 7 mg/l for doxyc...Continue Reading

Citations

Mar 29, 2019·Environmental Science and Pollution Research International·Xianliang YiHao Zhou
Apr 13, 2020·Archives of Environmental Contamination and Toxicology·Caio Rodrigues NobreCamilo Dias Seabra Pereira
Jun 22, 2020·Environmental Science and Pollution Research International·Jingzhe ZhouWei Li
May 30, 2019·International Journal of Molecular Sciences·Krystian Miazek, Beata Brozek-Pluska
Dec 12, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Kamrul Hassan SumanMahmudul Hasan Sikder
Nov 20, 2020·The Science of the Total Environment·Yejing HuangJinju Geng
Oct 23, 2020·Journal of Hazardous Materials·Youming DongZhengguo Song
Feb 13, 2021·The Science of the Total Environment·Alan RempelLuciane Maria Colla
Mar 8, 2021·The Science of the Total Environment·Joana C PrataTeresa Rocha-Santos
Nov 30, 2020·Journal of Hazardous Materials·Xiaying XinBaiyu Zhang
Apr 25, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sara MatthewsElvis Genbo Xu
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Nov 13, 2021·Environmental Science. Processes & Impacts·Honglu ZhuYifeng Zhang
Jan 15, 2022·Environmental Monitoring and Assessment·Reza PashaeiBoguslaw Buszewski

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