Influence of microsurgical varicocelectomy on human sperm mitochondrial DNA copy number: a pilot study.

Journal of Assisted Reproduction and Genetics
M S GabrielArmand Zini

Abstract

There is good evidence to show that varicocele repair can improve conventional sperm parameters, as well as, sperm DNA integrity, in infertile men with a clinical varicocele. To examine the effect of varicocelectomy on sperm quality, specifically, sperm nuclear chromatin integrity and sperm mitochondrial DNA (mtDNA) copy number. A prospective study done between March 2007 and January 2008. We evaluated a consecutive series of infertile men (n = 14) presenting to Ovo clinic with one year or more history of infertility, a clinically palpable varicocele and poor motility (<25 % rapid progressive and <50 % progressive). Microsurgical sub-inguinal varicocelectomy. Conventional sperm parameters, sperm mtDNA copy number (by real time PCR) and sperm chromatin structure assay (SCSA) parameters (%DFI,% HDS) before and 4 months after microsurgical varicocelectomy. Sperm concentration and SCSA parameters (%DFI and %HDS) improved significantly after surgery (P < 0.05). Sperm mitochondrial DNA copy number decreased significantly after surgery (27 ± 30 to 9 ± 6 copies per sperm, respectively, P = 0.032). There was a significant negative correlation between mitochondrial DNA copy number and sperm motility (r = - 0.71, P = 0.002). These finding...Continue Reading

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Citations

Dec 18, 2012·Asian Journal of Andrology·Sijo J Parekattil, Ahmet Gudeloglu
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Oct 5, 2021·Mitochondrion·Natalya KozhukharMikhail F Alexeyev

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