Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6J mice

Food & Function
Ramesh PothurajuSurender Jangra

Abstract

Obesity has become a major health problem in developed countries and is rapidly catching up in the developing world due to changes in their life style. Dietary incorporation of functional foods, including probiotic fermented milk and herbal ingredients, is being tried to ameliorate metabolic disorders. In the present study, the effect of dietary supplementation of a probiotic (Lactobacillus rhamnosus NCDC 17) fermented milk alone or either of the herbal preparations (Aloe vera/Gymnema sylvestre powders, 1% w/w) on the progression of obesity has been studied in C57BL/6J mice fed with a high fat diet for 12 weeks. At the end of the experimental period, oral administration of L. rhamnosus and herbs resulted in a significant decrease in the body weight, epididymal fat mass, fasting blood glucose and serum insulin levels. Supplementation of the probiotic L. rhamnosus alone and in combination with herbs showed a significant decrease in the adipocyte cell size and an increase in the number. Finally, obesity related adipokines levels were maintained at normal by the treatment groups. Thus, dietary intervention of milk fermented with probiotic L. rhamnosus alone or in combination with any of the herbal preparations seems to show anti-ob...Continue Reading

References

Nov 5, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A M GlennyC Wilson
Oct 17, 1998·Diabetes Care·S A EversonJ T Salonen
Jun 20, 2001·Biological & Pharmaceutical Bulletin·N ShigematsuM Okazaki
Oct 14, 2004·Diabetes, Obesity & Metabolism·Melania MancoGeltrude Mingrone
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Feb 27, 2007·Vascular Health and Risk Management·Rodolfo PaolettiAndrea Cignarella
Dec 7, 2007·FEBS Letters·Carl de Luca, Jerrold M Olefsky
Oct 22, 2008·Journal of Herbal Pharmacotherapy·Catherine UlbrichtWendy Weissner
Mar 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christina L Ohland, Wallace K Macnaughton
Jun 19, 2010·Experimental Biology and Medicine·Naoki TakemuraKei Sonoyama
Jan 14, 2011·Annual Review of Medicine·Giovanni MussoMaurizio Cassader
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
Oct 28, 2011·Science Translational Medicine·Nathan P McNultyJeffrey I Gordon
Aug 11, 2012·Journal of Nutritional Science and Vitaminology·Eriko MisawaKeiji Iwatsuki
Nov 1, 2012·Indian Journal of Pharmacology·Vinay KumarGeetika Khanna
May 30, 2013·World Journal of Gastroenterology : WJG·Li-Xin WangJi-Kui Hao
Oct 30, 2013·Journal of the Science of Food and Agriculture·Ramesh PothurajuPraveen Kumar Kavadi

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Citations

Dec 17, 2015·Phytotherapy Research : PTR·Ramesh PothurajuShaik Abdul Hussain
Mar 8, 2019·The Kaohsiung Journal of Medical Sciences·Cherng-Shyang ChangCheng-Yuan Kao
Jan 27, 2019·Nutrients·Kiran MazloomMihai Covasa
Mar 28, 2020·Current Pharmaceutical Design·Surender Jangra, Ramesh Pothuraju
Nov 1, 2016·Nutrition Today·Cindy D Davis

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