Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases.

Neuroscience
Noel Y CalingasanM F Beal

Abstract

Mitochondrial defects including reduction of a key mitochondrial tricarboxylic acid cycle enzyme alpha-ketoglutarate-dehydrogenase complex (KGDHC) are characteristic of many neurodegenerative diseases. KGDHC consists of alpha-ketoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (E2k), and dihydrolipoamide dehydrogenase (Dld) subunits. We investigated whether Dld or E2k deficiency influences adult brain neurogenesis using immunohistochemistry for the immature neuron markers, doublecortin (Dcx) and polysialic acid-neural cell adhesion molecule, as well as a marker for proliferation, proliferating cell nuclear antigen (PCNA). Both Dld- and E2k-deficient mice showed reduced Dcx-positive neuroblasts in the subgranular zone (SGZ) of the hippocampal dentate gyrus compared with wild-type mice. In the E2k knockout mice, increased immunoreactivity for the lipid peroxidation marker, malondialdehyde occurred in the SGZ. These alterations did not occur in the subventricular zone (SVZ). PCNA staining revealed decreased proliferation in the SGZ of E2k-deficient mice. In a transgenic mouse model of Alzheimer's disease, Dcx-positive cells in the SGZ were also reduced compared with wild type, but Dld deficiency did not exacerbate the r...Continue Reading

References

Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·M T JohnsonM S Patel
Mar 4, 2000·Alcoholism, Clinical and Experimental Research·L J MiC S Lieber
Jun 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daniel G HerreraJ Manuel Garcia-Verdugo
Nov 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Charles L LimoliJohn R Fike
Jan 19, 2005·The European Journal of Neuroscience·Sebastien Couillard-DespresLudwig Aigner
Jun 28, 2005·Neurological Research·Qing ZhangPingping Zuo
Aug 18, 2005·Neurobiology of Aging·B Mazur-KoleckaJ Frackowiak
Jan 18, 2006·Hippocampus·Liisa A M GaleaJodi L Pawluski
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti
Oct 20, 2006·International Journal of Radiation Biology·Charles L LimoliJohn R Fike
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tara L WalkerPerry F Bartlett
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gaëlle FriocourtJohn G Parnavelas
Jun 26, 2007·Neurobiology of Learning and Memory·Christina T Siwak-TappCarl W Cotman

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Citations

Mar 6, 2009·Journal of Inherited Metabolic Disease·K J Skvorak
Nov 23, 2012·Journal of Proteome Research·Dongmei SunXinsheng Lai
Jan 20, 2011·The Nurse Practitioner·Angela CumminsJulianne S Collins
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ludmila A VolobouevaRona G Giffard
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Armaz AschrafiBarry B Kaplan
Aug 29, 2014·Molecular Biology of the Cell·Manfred HeubleinMartin Ott
Mar 12, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gergely KissChristos Chinopoulos
Sep 30, 2010·Neurobiology of Disease·Jessica M SimpsonBrian R Christie
Sep 13, 2011·Journal of Neuroscience Research·Ludmila A Voloboueva, Rona G Giffard
Mar 5, 2011·Journal of Neuroscience Research·Linn Hege NilsenUrsula Sonnewald
Sep 18, 2012·Molecular and Cellular Neurosciences·Gary E GibsonJessica Elder
Jun 19, 2013·Cell Stem Cell·Run-Rui ZhangGuo-Liang Xu
Dec 6, 2014·Frontiers in Cellular Neuroscience·Emily L Casanova, Manuel F Casanova
Jul 6, 2016·Neuroscience and Biobehavioral Reviews·Giselli ScainiJoão Quevedo
Nov 23, 2018·Nature Reviews. Neuroscience·Mireille KhachoRuth S Slack
Nov 13, 2009·The Journal of Biological Chemistry·Marjorie GangolfLucien Bettendorff
Feb 15, 2019·Reviews in the Neurosciences·Nickolay K IsaevElisaveta E Genrikhs
May 24, 2019·Acta Physiologica·Jean-David GothiéSylvie Remaud
Apr 9, 2016·Oncotarget·Arianna CasciatiSimonetta Pazzaglia
Apr 24, 2014·Journal of Basic and Clinical Physiology and Pharmacology·Atish PrakashAnil Kumar
Aug 28, 2020·Frontiers in Aging Neuroscience·Alexandra M NicaiseStefano Pluchino
Jun 22, 2018·Frontiers in Neuroscience·Josh AllenLisa E Kalynchuk
Dec 24, 2013·Antioxidants & Redox Signaling·Yi-Bing OuyangRona G Giffard
Apr 12, 2021·Mitochondrion·Vivek Kumar SharmaVineet Mehta

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