Influence of mitral regurgitation repair on survival in the surgical treatment for ischemic heart failure trial.

Circulation
Marek A DejaRobert H Jones

Abstract

Whether mitral valve repair during coronary artery bypass grafting (CABG) improves survival in patients with ischemic mitral regurgitation (MR) remains unknown. Patients with ejection fraction ≤35% and coronary artery disease amenable to CABG were randomized at 99 sites worldwide to medical therapy with or without CABG. The decision to treat the mitral valve during CABG was left to the surgeon. The primary end point was mortality. Of 1212 randomized patients, 435 (36%) had none/trace MR, 554 (46%) had mild MR, 181 (15%) had moderate MR, and 39 (3%) had severe MR. In the medical arm, 70 deaths (32%) occurred in patients with none/trace MR, 114 (44%) in those with mild MR, and 58 (50%) in those with moderate to severe MR. In patients with moderate to severe MR, there were 29 deaths (53%) among 55 patients randomized to CABG who did not receive mitral surgery (hazard ratio versus medical therapy, 1.20; 95% confidence interval, 0.77-1.87) and 21 deaths (43%) among 49 patients who received mitral surgery (hazard ratio versus medical therapy, 0.62; 95% confidence interval, 0.35-1.08). After adjustment for baseline prognostic variables, the hazard ratio for CABG with mitral surgery versus CABG alone was 0.41 (95% confidence interval, ...Continue Reading

References

Oct 16, 2004·The New England Journal of Medicine·Robert A Levine
Apr 9, 2005·European Heart Journal·Patrizio LancellottiLuc A Piérard
Jul 26, 2005·The Annals of Thoracic Surgery·Daniel R WongDavid F Torchiana
Jun 5, 2007·Journal of the American College of Cardiology·Tomislav MihaljevicBruce W Lytle
Oct 9, 2007·The American Journal of Cardiology·Catherine A PastoriusKevin M Harris
Nov 21, 2007·The Journal of Thoracic and Cardiovascular Surgery·Eric J VelazquezUNKNOWN STICH Investigators
Jul 31, 2010·Journal of the American College of Cardiology·Robert H JonesJean-Lucien Rouleau
Aug 31, 2010·European Heart Journal·UNKNOWN Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for CardDavid Taggart
Sep 28, 2010·The Annals of Thoracic Surgery·Khalil FattouchGiovanni Ruvolo
Apr 6, 2011·The New England Journal of Medicine·Eric J VelazquezUNKNOWN STICH Investigators

❮ Previous
Next ❯

Citations

Jun 19, 2013·General Thoracic and Cardiovascular Surgery·Hitoshi YakuKazunari Okawa
Jun 19, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kevin C Allman
Oct 9, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jason H Rogers, Steven F Bolling
Jan 4, 2013·European Heart Journal·Bernard D Prendergast
Mar 20, 2014·European Journal of Internal Medicine·Enrico AmmiratiMaria Frigerio
Jun 25, 2014·Current Cardiology Reports·Mina M BenjaminPaul A Grayburn
Nov 19, 2014·The New England Journal of Medicine·Peter K SmithUNKNOWN Cardiothoracic Surgical Trials Network Investigators
Feb 19, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomislav KopjarBojan Biocina
Jan 19, 2016·Current Opinion in Cardiology·Neil P FamSubodh Verma
Jan 29, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Serenella CastelvecchioLorenzo Menicanti
Feb 4, 2014·The Canadian Journal of Cardiology·Jean L Rouleau, Robert O Bonow
Mar 23, 2013·Progress in Cardiovascular Diseases·Ramesh DaggubatiT Bruce Ferguson
Feb 27, 2013·The Canadian Journal of Cardiology·Ian PatersonJames A White
Sep 5, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Stephan WindeckerAdam Witkowski
Dec 30, 2014·Journal of the American College of Cardiology·Paul A GrayburnRobert J Siegel
Feb 14, 2015·Journal of the American College of Cardiology·Eric J Velazquez, Robert O Bonow
Jan 28, 2014·The Canadian Journal of Cardiology·Robin A DucasJames W Tam
Jul 6, 2014·The Canadian Journal of Cardiology·Bernard Iung, Alec Vahanian
Aug 26, 2014·JACC. Cardiovascular Interventions·Robert O Bonow
Mar 31, 2015·Journal of the American College of Cardiology·Anita W AsgarGregg W Stone
Dec 26, 2012·Journal of the American College of Cardiology·Robert O Bonow
Mar 19, 2013·Journal of the American College of Cardiology·Paul A Grayburn
Mar 19, 2013·Journal of the American College of Cardiology·Shahbudin H Rahimtoola
Apr 4, 2015·Heart Failure Clinics·Mohammad Sarraf, Ted Feldman
Dec 4, 2015·BioMed Research International·Giulio AgnettiFrancesco Nicolini
Jul 29, 2016·Current Opinion in Cardiology·Aeshita DwivediMuhamed Saric
Nov 1, 2016·Current Cardiology Reports·Zainab Samad, Eric J Velazquez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.