Influence of MMP inhibitor GM6001 loading of fibre coated polypropylene meshes on wound healing: Implications for hernia repair

Journal of Biomaterials Applications
Gabriele BöhmUrsula Mirastschijski

Abstract

Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum matrix metalloproteinase inhibitor GM6001. The aim was to modulate the inflammatory reaction, increase collagen deposition and improve mesh biointegration. Polypropylene meshes were surface-modified with star-configured NCO-sP(EO -stat-PO) and covered with electrospun nanofibres (polypropylene-nano) and GM6001 (polypropylene-nano-GM). In a hernia model, defects were reconstructed with one of the meshes. Inflammation, neovascularization, bio-integration, proliferation and apoptosis were assessed histologically, collagen content and gelatinases biochemically. Mesh surface modification resulted in higher inflammatory response compared to polypropylene. Pro-inflammatory matrix metalloproteinase-9 paralleled findings while GM6001 reduced matrix metalloproteinase-9 significantly. Significantly increased matrix metalloproteinase-2 beneficial for remodelling was noted with polypropylene-nano-meshes. Increased vascular end...Continue Reading

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Citations

Oct 19, 2019·IET Nanobiotechnology·Debalina BhattacharyaMainak Mukhopadhyay
Aug 13, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Quy LeSoheil Meshinchi

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Datasets Mentioned

BETA
GM6001

Methods Mentioned

BETA
sedation
light microscopy
electrophoresis

Software Mentioned

Image
Pro Plus
SAS

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