Influence of moderate energy restriction and seafood consumption on bone turnover in overweight young adults

The American Journal of Clinical Nutrition
Alice J LuceyMáireád Kiely

Abstract

Overweight and obesity are increasing in young adults. However, moderate energy restriction aimed at lowering body weight may promote bone turnover and bone loss. Inclusion of fish or fish oils in a weight-loss diet may attenuate these adverse skeletal effects. We examined the effects of incorporating fish or fish oil into an energy-restricted diet on bone turnover markers in young overweight adults. While following a strict hypoenergetic (-30% relative to estimated requirements) diet for 8 wk, 276 overweight men and women [body mass index (in kg/m(2)): 27.5-32.5; age: 20-40 y) were randomly assigned to 1 of 4 dietary groups: sunflower-oil capsules (3 g/d; control), cod (3 x 150 g/wk), salmon (3 x 150 g/wk), and fish-oil capsules (3 g/d). Body weight, bone biomarkers, and 25-hydroxyvitamin D were measured at baseline and endpoint. Data were analyzed with repeated-measures analysis of variance and general linear models. The mean (+/-SD) weight loss was 5.14 +/- 3.0 kg (5.8% +/- 3.2% body weight) during the 8 wk in the 4 dietary groups combined. Urinary N-telopeptides of type I collagen and serum C-terminal telopeptide of type I collagen increased (P < 0.05), whereas serum osteocalcin (but not bone-specific alkaline phosphatase) ...Continue Reading

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Citations

Apr 23, 2010·Obesity Surgery·Daniela Schaan CasagrandeBeatriz D'Agord Schaan
May 28, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jessica ZibelliniAmanda Sainsbury
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Sep 12, 2015·The American Journal of Clinical Nutrition·Ulrike LehmannJutta Dierkes
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Mar 20, 2009·The American Journal of Clinical Nutrition·Kevin D CashmanMairead Kiely
May 3, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Scott M SmithSara R Zwart
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