Influence of Modified Fucoidan and Related Sulfated Oligosaccharides on Hematopoiesis in Cyclophosphamide-Induced Mice

Marine Drugs
Natalia Yu AnisimovaNikolay E Nifantiev

Abstract

Immunosuppression derived after cytostatics application in cancer chemotherapy is considered as an adverse side effect that leads to deterioration of quality of life and risk of infectious diseases. A linear sulfated (1→3)-α-l-fucan M-Fuc prepared by chemical modification of a fucoidan isolated from the brown seaweed Chordaria flagelliformis, along with two structurally related synthetic sulfated oligosaccharides, were studied as stimulators of hematopoiesis on a model of cyclophosphamide immunosuppression in mice. Recombinant granulocyte colony-stimulating factor (r G-CSF), which is currently applied in medicine to treat low blood neutrophils, was used as a reference. Polysaccharide M-Fuc and sulfated difucoside DS did not demonstrate significant effect, while sulfated octasaccharide OS showed higher activity than r G-CSF, causing pronounced neutropoiesis stimulation. In addition, production of erythrocytes and platelets was enhanced after the octasaccharide administration. The assessment of populations of cells in blood and bone marrow of mice revealed the difference in mechanisms of action of OS and r G-CSF.

References

Jul 24, 2001·Current Drug Metabolism·Y Nieto
Mar 12, 2004·Carbohydrate Research·Maria I BilanAnatolii I Usov
Feb 14, 2007·Glycobiology·Albana CumashiUNKNOWN Consorzio Interuniversitario Nazionale per la Bio-Oncologia, Italy
Feb 15, 2011·Carbohydrate Research·Vadim B KrylovNikolay E Nifantiev
Oct 23, 2012·Nature Medicine·Ingrid G WinklerJean-Pierre Lévesque
Feb 22, 2014·BMC Pharmacology & Toxicology·Davide CrobuAndrea Di Stefano
Oct 28, 2014·International Journal of Molecular Sciences·Sun-A ImChong-Kil Lee
Oct 24, 2015·Cellular and Molecular Life Sciences : CMLS·Maria De GrandisMichel Aurrand-Lions
Nov 7, 2015·Biochemistry. Biokhimii︠a︡·N Yu AnisimovaM V Kiselevskiy
Aug 18, 2018·The Biochemical Journal·Anthony J Hayes, James Melrose

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Citations

Oct 12, 2019·Marine Drugs·Helen J FittonSamuel N Karpiniec
Nov 22, 2019·International Journal of Biological Macromolecules·Chao LiGuangli Yu

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Methods Mentioned

BETA
light microscopy

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