Influence of molecular structure on the properties of out-of-equilibrium oscillating enzymatic reaction networks

Journal of the American Chemical Society
Albert S Y WongWilhelm T S Huck

Abstract

Our knowledge of the properties and dynamics of complex molecular reaction networks, for example those found in living systems, considerably lags behind the understanding of elementary chemical reactions. In part, this is because chemical reactions networks are nonlinear systems that operate under conditions far from equilibrium. Of particular interest is the role of individual reaction rates on the stability of the network output. In this research we use a rational approach combined with computational methods, to produce complex behavior (in our case oscillations) and show that small changes in molecular structure are sufficient to impart large changes in network behavior.

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Citations

May 28, 2016·ACS Synthetic Biology·Ting-Ru ChenPawel L Urban
May 10, 2017·Angewandte Chemie·Yasunori Okamoto, Thomas R Ward
Jan 31, 2017·Chemical Society Reviews·Rémi Merindol, Andreas Walther
Jun 28, 2017·ACS Applied Materials & Interfaces·Hanna M MaltanavaEkaterina V Skorb
Aug 29, 2017·Beilstein Journal of Organic Chemistry·Albert S Y Wong, Wilhelm T S Huck
Dec 7, 2019·Chemistry : a European Journal·Oliver R MaguireWilhelm T S Huck
Mar 23, 2020·The Journal of Chemical Physics·Mark Dittner, Bernd Hartke
Jan 11, 2017·Angewandte Chemie·Sjoerd G J PostmaWilhelm T S Huck
Nov 11, 2019·Emerging Topics in Life Sciences·Oliver R Maguire, Wilhelm T S Huck
May 22, 2021·Nature Communications·Alexander I NovichkovSergey N Semenov
Oct 19, 2017·Journal of the American Chemical Society·Aleksandr A PogodaevWilhelm T S Huck
Jun 6, 2017·Journal of the American Chemical Society·Albert S Y WongWilhelm T S Huck

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