PMID: 9444385Jan 28, 1998Paper

Influence of monomethylfumarate on monocytic cytokine formation--explanation for adverse and therapeutic effects in psoriasis?

Archives of Dermatological Research
Khusru AsadullahW D Döcke

Abstract

Although the effectiveness of systemic antipsoriatic treatment with fumaric acid esters has been proven, their mode of action is still not understood. Recent results indicate their potency in inducing cytokine production in stimulated T cells. Since monocytes and their cytokines are also considered to be of pathogenic importance in psoriasis, we investigated the effect of monomethylfumarate (MMF) on proinflammatory (TNF-alpha, IL-12) and antiinflammatory (IL-10, IL-1RA) cytokine production by peripheral blood mononuclear cells (PBMC) and separated monocytes. In 24-h PBMC cultures from both psoriatic patients (n = 6-13) and healthy volunteers (n = 7-9), MMF at 100 microM induced secretion of TNF-alpha, IL-10, and IL-1RA. Kinetics of IL-10 protein and mRNA expression indicated de novo production. Moreover, MMF significantly augmented endotoxin-induced synthesis of TNF-alpha, IL-10 and IL-1RA. In contrast, no influence on IL-12 secretion was found. Similar effects of MMF in purified monocytes indicated these cells to be responsible for aberrant cytokine formation. Furthermore, enhanced expression of costimulatory molecules after MMF stimulation confirmed monocyte activation. Multiple restimulation with fumaric acid esters in vitro...Continue Reading

Citations

Sep 26, 2013·Current Neurology and Neuroscience Reports·Ralf A Linker, Ralf Gold
Apr 24, 2013·Drugs·Rehiana AliPaolo Antonio Muraro
Oct 1, 2013·Neuroscience Letters·Karelle BénardaisMartin Stangel
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J M Sempere-OrtellsJ Pardo
Nov 17, 1999·Clinical and Experimental Dermatology·M Ameen, R Russell-Jones
Mar 21, 1998·The Journal of Clinical Investigation·K AsadullahW D Döcke
Jun 1, 2011·Drug Design, Development and Therapy·Richard NicholasPaolo A Muraro
Nov 4, 2000·Expert Opinion on Investigational Drugs·K AsadullahW Sterry
Jan 20, 2016·Annals of Clinical and Translational Neurology·Mackenzie A Michell-RobinsonJack P Antel
Mar 19, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R GoldM Stangel
Feb 17, 2001·The Journal of Investigative Dermatology·K Zhu, U Mrowietz
Mar 12, 2002·The Journal of Investigative Dermatology·R LoeweP Petzelbauer
Sep 2, 2008·Archives of Medical Research·Marina MilenkovićZorica Stojić-Vukanić
Sep 27, 2005·The British Journal of Dermatology·A KreuterT Gambichler
Aug 12, 2015·Seminars in Immunopathology·Luke M HealyJack P Antel
Dec 26, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN Germany Society for Dermatology
Jul 11, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN Berufsverband Deutscher Dermatologen (BVDD)
Jan 26, 2006·The British Journal of Dermatology·N H R LitjensP H Nibbering
Dec 17, 2003·The Journal of Investigative Dermatology·Felix TreumerUlrich Mrowietz
Mar 31, 2015·Frontiers in Immunology·Gillian Margaret TannahillStefano Pluchino
Jul 6, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Ralf GoldNuwan C Kurukulasuriya
Nov 28, 2017·Frontiers in Immunology·Stephanie A AmiciMireia Guerau-de-Arellano
Jul 20, 2016·Therapeutic Advances in Chronic Disease·Ralf A Linker, Aiden Haghikia
Apr 12, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN Berufsverband Deutscher Dermatologen (BVDD)
Mar 5, 2020·Expert Opinion on Drug Safety·Radomir Reszke, Jacek C Szepietowski
Jun 11, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Paula R G KempeAlexandre L R de Oliveira
Mar 27, 2002·BMC Dermatology·Alexander KreuterNorbert H Brockmeyer
Jan 20, 2007·The Journal of Investigative Dermatology·Joachim C U LehmannWolf-Dietrich F Docke
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcelo FarinaLuciano Saso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.