Influence of Morbid Obesity and Bariatric Surgery Impact on the Carotid Adventitial Vasa Vasorum Signal.

Obesity Surgery
Ferran RiusAlbert Lecube

Abstract

Adventitial vasa vasorum (VV) expansion to the avascular intima precedes an increase in carotid intima-media thickness. However, factors involved in the development of the atherosclerotic process and its reversibility remain unclear. We aimed to evaluate the VV signal in both morbid obesity and after bariatric surgery (BS). We conducted a case-control study to examine the VV signal in the carotid of 40 morbidly obese patients and 40 non-obese controls. The effect of BS was evaluated in 33 patients. Contrast-enhanced carotid ultrasound was used to assess the VV signal. The mean VV density was higher in obese than in non-obese subjects (0.739 ± 0.117 vs. 0.570 ± 0.111, p < 0.001). The VV signal positively correlated with BMI (p < 0.001) and waist circumference (p = 0.001) but was not related to cIMT. The stepwise multivariate regression analysis revealed that waist circumference (beta = 0.507, p < 0.001) together with fasting plasma glucose (beta = 0.229, p = 0.024) were independently associated with the VV signal (R2 = 0.382). Before BS, the median VV signal correlated with soluble intercellular adhesion molecule 1 (p = 0.022). After a 12-month follow-up, a 12.0% decrease in VV (0.731 ± 0.126 vs. 0.643 ± 0.115, p = 0.003) was ob...Continue Reading

References

Oct 1, 1992·European Journal of Immunology·E J von AsmuthW A Buurman
Nov 13, 2003·Atherosclerosis·Stefan BlankenbergLaurence Tiret
Mar 24, 2005·The New England Journal of Medicine·S Jay OlshanskyDavid S Ludwig
Jul 18, 2006·Journal of the American College of Cardiology·Steven B Feinstein
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
Aug 19, 2008·Current Atherosclerosis Reports·Blai Coll, Steven B Feinstein
Feb 26, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·V G AthyrosD P Mikhailidis
Jan 5, 2012·JAMA : the Journal of the American Medical Association·Lars SjöströmLena M S Carlsson
Jan 10, 2013·Obesity Surgery·Kourosh SarkhoshShahzeer Karmali
Mar 2, 2013·Current Pharmaceutical Design·Maria Dolores MauricioJosé María Vila
Mar 13, 2013·Atherosclerosis·Maria Vittoria ArcidiaconoDidac Mauricio
Apr 16, 2013·Cell Metabolism·Tamara TchkoniaJames L Kirkland
Dec 11, 2013·Journal of Stroke·Sanne A E Peters, Michiel L Bots
Mar 26, 2014·The Annals of Pharmacotherapy·Sheila M WilhelmPramodini B Kale-Pradhan
Jun 17, 2014·Echocardiography·Uchechukwu K A SampsonSteve B Feinstein
Feb 11, 2015·The Canadian Journal of Cardiology·David Garcia-LabbéPaul Poirier
Jun 13, 2015·Atherosclerosis·Esther RubinatDidac Mauricio
Sep 22, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R LupoliG Mingrone
Jan 19, 2016·Trends in Cardiovascular Medicine·Glenn K Lee, Yong-Mei Cha
Jul 9, 2016·Obesity Surgery·Federico MarchesiLuigi Roncoroni
Jan 31, 2017·Mediators of Inflammation·Maria Vittoria ArcidiaconoMercè Borràs

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Related Papers

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
A Rogowicz-FrontczakB Wierusz-Wysocka
European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
Marco MagnoniAttilio Maseri
© 2022 Meta ULC. All rights reserved