Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA

Journal of Microencapsulation
Cuifang CaiThomas Kissel

Abstract

The aim of the present work was to understand the collaborative roles and the comprehensive effects of polymer nature, morphology, drug distribution and release behaviour for PLGA microspheres prepared by the double emulsion method. The morphology and drug distribution of the FITC-dextran-loaded microspheres were investigated by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM), respectively. The results show that the morphology and release profiles depend on the polymer nature. For the capped PLGA RG502, the porosity, pore size and drug distribution had no pronounced influence on the release profile beyond the initial release. No significant changes in size and morphology were found and there was negligible water uptake during the release process. PEG addition as a pore maker indicated a possible way to modify the release rate at the second release stage. However, in the case of the uncapped PLGA RG503H, release profiles were dependent upon changes in porosity, pore size and drug loading. Increases in porosity, internal pore size and loading resulted in a continuous release profile. Previous studies have shown the importance of different process parameters on morphology and drug release, but in t...Continue Reading

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Citations

Jul 17, 2013·Drug Development and Industrial Pharmacy·Hesham M TawfeekGillian A Hutcheon
Jul 28, 2012·Expert Opinion on Drug Delivery·Shirui MaoLuk Chiu Li
Mar 2, 2011·International Journal of Pharmaceutics·Reginaldo A TrindadeMaria H Bueno da Costa
Apr 22, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yihan XuDonghun Koo
Aug 15, 2014·Nanotechnology·Azita HaddadiAfsaneh Lavasanifar
Sep 16, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei-Li LaracuenteKevin J McHugh

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