Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways

The American Journal of Gastroenterology
Rosario CuomoJan Tack

Abstract

Motilin agonists are strong gastroprokinetics, but their impact on symptoms in delayed gastric emptying has been disappointing. It has been speculated that it is due to the contractile effect of motilin agonists on the proximal stomach, but the pathway involved and the symptomatic consequences have been incompletely elucidated. To study whether motilin enhances proximal stomach tone and enhances meal-induced satiety and to evaluate whether this effect involves a cholinergic pathway. A gastric barostat was used to study, in healthy subjects, the effect of motilin (300 ng/kg/30 min i.v.) or saline on fasting gastric fundus tone and on post-prandial relaxation. To evaluate the involvement of a cholinergic pathway, atropine (12 microg/kg/h) was administered intravenously simultaneously with or before and during motilin infusion in the fasting state. Finally, a satiety drinking test was performed in 21 subjects twice after pretreatment with placebo or motilin and with placebo or atropine. Administration of motilin caused a significant increase of fasting fundus tone expressed as decrease of the mean balloon volume (324 +/- 60 mL vs 213 +/- 62 mL, p < 0.05). Simultaneous administration of atropine and motilin did not generate a signi...Continue Reading

References

Jul 1, 1979·Digestive Diseases and Sciences·G VantrappenJ Hellemans
Oct 1, 1992·Digestive Diseases and Sciences·M BoivinP Poitras
Jan 1, 1992·Gastroenterology·T L PeetersR Bouillon
Apr 12, 1990·The New England Journal of Medicine·J JanssensR Bouillon
Sep 1, 1989·Pflügers Archiv : European journal of physiology·F E LüdtkeK Golenhofen
Jan 1, 1988·The British Journal of Radiology·P J CollinsB E Chatterton
Oct 1, 1988·The Journal of Surgical Research·J F Kuemmerle, J M Kellum
Sep 1, 1986·Regulatory Peptides·V BormansG Vantrappen
Mar 5, 1984·Life Sciences·J E FoxH Robotham
Jul 1, 1995·Gastroenterology·S Bruley des VarannesJ P Galmiche
Jan 1, 1997·Peptides·Z Itoh
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·P MillerP Poitras
Aug 20, 2002·Digestive Diseases and Sciences·I M C KamerlingA A M Masclee
May 10, 2003·The American Journal of Gastroenterology·Giovanni SarnelliJan Tack
Oct 24, 2003·The American Journal of Gastroenterology·Magnus SimrénJan Tack

❮ Previous
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Citations

Aug 28, 2010·International Journal of Peptides·Tetsuro OhnoHiroyuki Kuwano
Oct 4, 2011·Clinical Interventions in Aging·Paul GlareRoma Tickoo
Oct 13, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R TutuianJ Tack
Feb 9, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G J Sanger, D H Alpers
Mar 29, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S KindtJ Tack
Feb 16, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R S ChoungA R Zinsmeister
Nov 15, 2006·Gastroenterology·Filippo CremoniniAlan R Zinsmeister
Jun 16, 2011·The Journal of International Medical Research·F KiraK Ogura
Jul 20, 2006·Digestive Diseases·G Karamanolis, J Tack
Nov 22, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Francesco Paolo ZitoRosario Cuomo
Mar 1, 2008·Nature Reviews. Drug Discovery·Gareth J Sanger, Kevin Lee
May 9, 2008·Digestive Diseases·Kostas Mimidis, Jan Tack
Apr 10, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·D T Beattie, J A M Smith
May 17, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B GeeraertsJ Tack
Feb 13, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D AngJ Tack
Jun 4, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S LayecC-H Malbert
Feb 6, 2008·Alimentary Pharmacology & Therapeutics·A Patrick, O Epstein
Dec 7, 2013·Journal of Gastroenterology·Fernando AzpirozJan Tack
Oct 5, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brecht GeeraertsJan Tack
Jul 21, 2011·American Journal of Physiology. Endocrinology and Metabolism·Pierre MiegueuDavid H St-Pierre
May 24, 2012·British Journal of Pharmacology·Inge Depoortere
Apr 11, 2019·The Journal of Pharmacology and Experimental Therapeutics·Yumi HaradaHiroyuki Kobayashi
Jan 31, 2020·Expert Review of Gastroenterology & Hepatology·Kanageswari SingaramMaxim S Petrov
Jan 11, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Pierre Poitras, Theo L Peeters
Jul 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Priya VijayvargiyaMichael Camilleri
Sep 9, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R HobsonG E Dukes
Oct 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A D NelsonD Burton
Apr 11, 2018·The American Journal of Clinical Nutrition·Eveline DelooseJan Tack
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack
Oct 23, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pieter Vanden BergheJan Tack
Feb 2, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Karen Van den HouteJan Tack
Mar 15, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nora SchaubDaniel Sifrim
Dec 17, 2009·British Journal of Pharmacology·Inge DepoortereJan Tack
Apr 2, 2011·Journal of Gastroenterology and Hepatology·Kazuma OgisoAkio Inui
May 22, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E ScarpelliniJ Tack
Oct 31, 2017·BioMed Research International·Giuseppe RiezzoFrancesco Russo
Apr 8, 2020·Frontiers in Psychiatry·Karen Van den HouteJan Tack
Jan 5, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P JanssenJ Tack
Feb 24, 2011·Alimentary Pharmacology & Therapeutics·P JanssenJ Tack
Oct 29, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J TackG Tougas

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