Influence of mouse strain, infective dose and larval burden in the brain on activity in Toxocara-infected mice

Journal of Helminthology
D M Cox, C V Holland

Abstract

Outbred LACA mice and inbred NIH mice were administered low (100 ova), medium (1000 ova), high (3000 ova) and trickle (4x250 ova) doses of Toxocara canis ova and the effect of infection on activity was examined with respect to: (i) the dose of ova administered and (ii) the number of larvae recovered from the brain. Larval recovery from the brain was significantly reduced in NIH mice compared to LACA mice for the 1000, 3000 and trickle doses. Mice from each strain were divided into larval intensity groupings based upon the number of larvae recovered from their brain. Activity for each mouse was measured pre- and post-infection by observing its behaviour in the home cage. Activity was assessed by monitoring six different independent categories of murine behaviour - ambulation, grooming, rearing, digging, climbing and immobility. Within each behavioural category, the duration of time spent at each behaviour per mouse within one thousandth of a second, the number of short bouts performed and the number of long bouts of behaviour performed were recorded over a 20 min period. Activity of LACA and NIH mice differed prior to infection. LACA mice spent more time immobile compared to NIH mice, which ambulated and climbed more. Variations...Continue Reading

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Citations

May 4, 2011·Parasitology Research·Petra KolbekováLibuše Kolářová
Jan 15, 2013·Veterinary Parasitology·Christina StrubeElisabeth Janecek
Apr 27, 2017·Memórias do Instituto Oswaldo Cruz·Gabriela Rodrigues E FonsecaSusana Angélica Zevallos Lescano
Jul 31, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Flávia Motta CorrêaSergio Vieira dos Santos
Apr 25, 2009·Revista Do Instituto De Medicina Tropical De São Paulo·Pedro P ChieffiAntonia G Nasello
Feb 7, 2008·Parasite Immunology·C M HamiltonE Pinelli
May 28, 2021·Research and Reports in Tropical Medicine·Pedro Paulo ChieffiSergio Vieira Dos Santos

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