Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge

Virology
Lynda A MorrisonD M Knipe

Abstract

Herpes simplex virus (HSV) most frequently initiates infection at a mucosal surface; thus mucosal immune responses are likely to be important in defense against HSV infection. We have examined the effects of eliciting mucosal as well as systemic immune responses on protection against genital challenge infection with virulent HSV-2 in mice immunized with a replication-defective mutant of HSV-2. In addition, we have examined the types of immune responses elicited by immunization by the different routes under conditions known to provide protection. We observed that immunizations at parenteral and distal mucosal sites generate immune responses that have an additive effect in protection against challenge infection with virulent HSV-2. Immunization at either of these sites alone prevented paralysis and death after challenge virus infection and reduced replication of the challenge virus in the genital mucosa, although subcutaneous immunization was more effective in reducing virus replication. Simultaneous immunization at the two sites led to the greatest reduction in mucosal replication of challenge virus. The type of response generated was also affected by the route of immunization. Subcutaneous immunization results in a strong syste...Continue Reading

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Citations

Sep 11, 2010·Nature Reviews. Immunology·Akiko Iwasaki
Dec 3, 2008·The Journal of Experimental Medicine·Norifumi IijimaAkiko Iwasaki
Feb 17, 2001·Infection and Immunity·J U IgietsemeL L Perry
Mar 24, 2007·Annual Review of Immunology·Akiko Iwasaki
Aug 1, 2006·The Journal of Clinical Investigation·Hong Shen, Akiko Iwasaki
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·X J Da CostaD M Knipe
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Norifumi IijimaAkiko Iwasaki
Sep 10, 2013·Trends in Immunology·Haina Shin, Akiko Iwasaki
Jan 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ji Eun OhHeung Kyu Lee
Jan 25, 2012·Antiviral Research·Andrey ShestakovKristina Eriksson
Nov 10, 2006·Journal of Reproductive Immunology·Alexandra SvenssonKristina Eriksson
Aug 21, 2013·Immunological Reviews·Haina Shin, Akiko Iwasaki
Apr 3, 2016·Cellular and Molecular Life Sciences : CMLS·Hongmei FuFederica M Marelli-Berg
Jul 4, 2015·Canadian Journal of Microbiology·Elizabeth González AznarOliver Pérez
Feb 23, 2010·Immunity·Heung Kyu LeeAkiko Iwasaki

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