Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary

Reproduction : the Official Journal of the Society for the Study of Fertility
Rachel C HirstHarry M Charlton

Abstract

Measurement of inhibins A and B in the serum of normal cyclic rodents has implicated FSH in the regulation of these peptides within the ovary. To extend these observations we have used a panel of mutant mice carrying mutations which affect either the production of, or the ability to respond to, FSH and LH. As a consequence, the females are infertile and show different degrees of follicular development. The aim of this study was to measure inhibin gene transcription in the ovaries of these mutant females together with inhibin protein levels in ovaries and serum and to relate these to follicular development within the ovary. Comparison was made with a pool of normal/heterozygous females. In hpg females where lack of GnRH production results in the absence of gonadotropin synthesis, in FSHbeta knockout (FSHbetaKO) females where disruption of the gene encoding FSHbeta results in the absence of FSH production, and in FSH receptor knockout (FSHRKO) females which are unable to respond to circulating FSH, follicular development remains at the pre-antral stage in these three mutants. Only in the hpg females were common inhibin alpha subunit mRNA levels significantly lower than normal. In these three mutants, however, mRNA levels for both...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·N B Schwartz, C P Channing
Sep 2, 1976·Nature·F H De Jong, R M Sharpe
Dec 1, 1991·Molecular Endocrinology·S K KendallS A Camper
Feb 1, 1991·Molecular and Cellular Endocrinology·S G HillierA J Mason
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K E MayoW Vale
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R G ForageJ K Findlay
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J HsuehW Vale
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N LingR Guillemin
Jan 16, 1985·Biochemical and Biophysical Research Communications·D M RobertsonD M de Kretser
Jan 1, 1994·Reproduction, Fertility, and Development·J K Findlay

❮ Previous
Next ❯

Citations

Aug 24, 2012·Journal of Assisted Reproduction and Genetics·Leandros A LazarosIoannis A Georgiou
Jan 13, 2009·Journal of Molecular Endocrinology·M H AbelP J O'Shaughnessy
Dec 13, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Ilpo Huhtaniemi, Maria Alevizaki
May 27, 2006·Human Reproduction Update·K R BarnettJ A Flaws

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.