Influence of n-6 and n-3 polyunsaturated fatty acids on the resistance to experimental tuberculosis

Metabolism: Clinical and Experimental
K PaulH J Bremer

Abstract

It has previously been shown that the n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (20:5(n-3)) and docosahexaenoic acid (22:6(n-3)) possess antiinflammatory properties and can interfere with immune functions. To evaluate whether this would affect resistance to infection, we studied the influence of different types of fatty acids (FAs) on experimental tuberculosis in an animal model. Three groups of 26 weanling guinea pigs were fed isocaloric diets with 26 cal% fat that differed in FA composition with respect to saturated FAs, linoleic acid (18:2(n-6)), eicosapentaenoic acid (20:5(n-3)), and docosanexaenoic acid (22:6(n-3)) as follows: (1) reference (REF) group: 14.8 cal% saturated FAs and 2.8 cal% linoleic acid; (2) n-6 group: 4.6 cal% saturated FAs and 15.4 cal% linoleic acid; (3) n-3 group: 6.3 cal% saturated FAs, 10 cal% linoleic acid, 1.4 cal% eicosapentaenoic acid, and 0.9 cal% docosahexaenoic acid. After 13 weeks, 18 animals from each group were intramuscularly injected with 180 colony-forming units (CFU) Mycobacterium tuberculosis strain H37Rv. Eight noninfected animals per group served as controls. Seven weeks later, the mean number of mycobacteria recovered from the spleens of the n-3 group (log 4.34 C...Continue Reading

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Citations

Jun 11, 2020·Seminars in Immunopathology·Renata RamalhoMarkus Maeurer
Sep 3, 2002·Clinical and Diagnostic Laboratory Immunology·Manuel A de PabloGerardo Alvarez de Cienfuegos
Apr 6, 2004·Scandinavian Journal of Infectious Diseases·Valtýr Stefánsson ThorsAsgeir Haraldsson
Jan 29, 2000·Immunology and Cell Biology·M A de Pablo, G Alvarez de Cienfuegos
Dec 7, 2002·The Journal of Nutrition·Michele Anderson, Kevin L Fritsche
Jan 21, 2000·FEMS Immunology and Medical Microbiology·M A de PabloG Alvarez de Cienfuegos
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·María A PuertollanoGerardo Alvarez de Cienfuegos
Jul 31, 2004·Immunology and Cell Biology·María A PuertollanoGerardo Alvarez De Cienfuegos
Jun 25, 2009·The Journal of Nutrition·Nicole M J SchwerbrockMelinda A Beck
Dec 11, 2013·Periodontology 2000·Dolphus R DawsonJeffrey L Ebersole
Oct 22, 2008·The Journal of Nutrition·Christine T McFarlandDavid N McMurray
Dec 19, 2000·FEMS Immunology and Medical Microbiology·M A de PabloG Alvarez de Cienfuegos
Dec 26, 2001·FEMS Immunology and Medical Microbiology·M A PuertollanoG Alvarez de Cienfuegos
Jul 30, 2011·Chemistry and Physics of Lipids·David N McMurrayRobert S Chapkin
Sep 10, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L A Horrocks, Y K Yeo

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