Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis

European Respiratory Review : an Official Journal of the European Respiratory Society
Mario CazzolaMaria Gabriella Matera

Abstract

In order to clarify the possible role of N-acetylcysteine (NAC) in the treatment of patients with chronic bronchitis and chronic obstructive pulmonary disease (COPD), we have carried out a meta-analysis testing the available evidence that NAC treatment may be effective in preventing exacerbations of chronic bronchitis or COPD and evaluating whether there is a substantial difference between the responses induced by low (≤ 600 mg per day) and high (> 600 mg per day) doses of NAC. The results of the present meta-analysis (13 studies, 4155 COPD patients, NAC n = 1933; placebo or controls n = 2222) showed that patients treated with NAC had significantly and consistently fewer exacerbations of chronic bronchitis or COPD (relative risk 0.75, 95% CI 0.66-0.84; p < 0.01), although this protective effect was more apparent in patients without evidence of airway obstruction. However, high doses of NAC were also effective in patients suffering from COPD diagnosed using spirometric criteria (relative risk 0.75, 95% CI 0.68-0.82; p = 0.04). NAC was well tolerated and the risk of adverse reactions was not dose-dependent (low doses relative risk 0.93, 95% CI 0.89-0.97; p = 0.40; high doses relative risk 1.11, 95% CI 0.89-1.39; p = 0.58). The st...Continue Reading

References

Mar 22, 1976·European Journal of Clinical Pharmacology·C Grassi, G C Morandini
May 1, 1984·The American Review of Respiratory Disease·K JamalW M Thurlbeck
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Nov 27, 1999·Respiration; International Review of Thoracic Diseases·R PelaC M Sanguinetti
Sep 1, 2000·The European Respiratory Journal·C SteyM R Tramèr
May 27, 2003·The European Respiratory Journal·C M J M GerritsJ W J Lammers
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Mar 17, 2007·COPD·E Rand SutherlandRussell P Bowler
Nov 6, 2007·The European Respiratory Journal·G ViegiL Carrozzi
Jan 14, 2009·Respiratory Medicine·Tjard SchermerChris van Weel
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Dec 27, 2011·Archivos de bronconeumología·Marc MiravitllesJuan José Soler-Cataluña
Aug 21, 2013·Journal of Medical Internet Research·Salimah Z ShariffAmit X Garg
Mar 14, 2014·The Lancet. Respiratory Medicine·Mario Cazzola, Maria Gabriella Matera
Apr 16, 2014·The Journal of Clinical Hypertension·J Rick Turner, Todd A Durham
May 2, 2014·Molecular Diagnosis & Therapy·Andrea SegretiMario Cazzola
May 17, 2014·Chest·Hoi Nam TseCee Zhung Steven Tseng

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Citations

Nov 17, 2015·Expert Review of Respiratory Medicine·Maria Gabriella MateraMario Cazzola
Feb 20, 2016·Expert Opinion on Pharmacotherapy·Mario CazzolaMaria Gabriella Matera
Sep 1, 2015·Drugs·Mario CazzolaMaria Gabriella Matera
Nov 1, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Arvind PandaySanjay Batra
Jun 10, 2016·Expert Opinion on Drug Safety·Paola RoglianiMaria Gabriella Matera
Sep 2, 2016·American Journal of Respiratory and Critical Care Medicine·Dave SinghFernando J Martinez
Feb 18, 2017·Journal of Clinical Medicine·Adam John Anthony McGuinness, Elizabeth Sapey
Jan 28, 2017·American Journal of Respiratory and Critical Care Medicine·Claus F VogelmeierAlvar Agustí
Feb 6, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Claus F VogelmeierAlvar Agusti
Mar 16, 2017·Equine Veterinary Journal·L CalzettaM G Matera
Apr 27, 2017·FEMS Microbiology Letters·Charlotte VolgersFrank R M Stassen
Jan 25, 2018·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Frederico Leon Arrabal FernandesFernando Luiz Cavalcanti Lundgren
Oct 31, 2017·Expert Review of Respiratory Medicine·Mario CazzolaMaria Gabriella Matera
Jul 5, 2018·Expert Review of Respiratory Medicine·Luigino CalzettaMario Cazzola
Jul 19, 2018·QJM : Monthly Journal of the Association of Physicians·S Moitra
Nov 1, 2016·Antimicrobial Agents and Chemotherapy·Giulia LandiniLucia Pallecchi
Jan 18, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Luigino CalzettaMaria Gabriella Matera
Jan 18, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kun TangJianmiao Wang
May 21, 2019·The Cochrane Database of Systematic Reviews·Phillippa PooleRebecca Fortescue
Jun 22, 2017·Respiratory Research·Marc MiravitllesJosé R Jardim
Aug 20, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin
Nov 28, 2019·Mucosal Immunology·C YoungN Du Plessis
Aug 21, 2020·The Journal of International Medical Research·Ruxandra UlmeanuFlorin Mihaltan
Sep 11, 2018·Expert Opinion on Pharmacotherapy·Neil C Thomson
Jul 28, 2020·Antioxidants·Francesca SilvagnoGian Piero Pescarmona
Jul 16, 2020·Therapeutic Advances in Respiratory Disease·Aishath Fazleen, Tom Wilkinson
Apr 20, 2018·Oxidative Medicine and Cellular Longevity·Andrew J O'LearyKen D O'Halloran
Dec 16, 2017·Expert Review of Respiratory Medicine·Paola RoglianiGiuseppe De Angelis
Mar 30, 2018·Cellular and Molecular Life Sciences : CMLS·Birke J BenedikterFrank R M Stassen
Mar 2, 2017·Molecular Diagnosis & Therapy·Mario CazzolaMaria Gabriella Matera
Aug 22, 2020·Therapeutic Advances in Gastroenterology·Chieh-Chang ChenUNKNOWN and for the Taiwan Gastrointestinal Disease and Helicobacter Consortium
Jan 1, 2019·Current Otorhinolaryngology Reports·Sidney S Braman, Armeen Poor

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