Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis

The Journal of Antimicrobial Chemotherapy
C Pérez-GiraldoA C Gómez-García

Abstract

The influence of various concentrations (0.003-8 mg/mL) of N-acetylcysteine on the formation of biofilms by 15 strains of Staphylococcus epidermidis has been studied. A dose-related decrease in biofilm formation was observed, except with the lowest concentrations. The 'slime' index relative to the control was 63%, 55%, 46%, 34%, 26% and 26% in the presence of 0.25, 0.5, 1, 2, 4, and 8 mg/mL of N-acetylcysteine, respectively. These data are statistically significant. The inhibitory effect of 2 mg/mL of N-acetylcysteine on slime formation was also verified by electron microscopy.

Associated Clinical Trials

Citations

Aug 24, 2013·International Journal of Oral Science·Luiz Fernando Machado SilveiraCarmen María Ferrer-Luque
Apr 27, 2011·American Journal of Therapeutics·Bruna LeiteRosário Oliveira
Dec 22, 2010·Antimicrobial Agents and Chemotherapy·Mei-Hui LinShih-Tung Liu
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Saima AslamRabih O Darouiche
Nov 2, 2012·Antimicrobial Agents and Chemotherapy·Mohammad D MansouriRabih O Darouiche
May 14, 2010·BMC Microbiology·Tiemei Zhao, Youning Liu
Sep 11, 2013·International Journal of Molecular Sciences·Meng ChenHongmin Sun
Apr 18, 2014·Current Urology Reports·R Charles WelliverTobias S Köhler
Oct 13, 2011·Journal of Clinical Gastroenterology·Kian Makipour, Frank K Friedenberg
Jul 9, 2014·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Jane LeaBrian D Westerberg
Jan 27, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Seisuke NishimuraHiroyuki Shindo
Mar 10, 2016·Journal of Conservative Dentistry : JCD·Udayakumar PalaniswamySwathi Aravelli
May 7, 2013·Enfermedades infecciosas y microbiología clínica·Bruna LeiteRosário Oliveira
Sep 18, 2015·Archives of Microbiology·Priya GuptaProsun Tribedi
Dec 14, 2011·Journal of Endodontics·Samantha Yiling QuahKai Soo Tan
Sep 4, 2015·American Journal of Respiratory and Critical Care Medicine·Justin M OldhamUNKNOWN IPFnet Investigators
Apr 15, 2008·Journal of Colloid and Interface Science·Henk J BusscherHenny C Van der Mei
Feb 13, 2007·International Journal of Antimicrobial Agents·Mohammad D Mansouri, Rabih O Darouiche
Oct 6, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lígia RodriguesRosário Oliveira
May 21, 2013·Journal of Chemotherapy·Carlo L RomanòLorenzo Drago
Jun 9, 2009·Journal of Medical Microbiology·Mohan VenkateshJames Versalovic
Aug 12, 2014·Journal of Medical Microbiology·Moira J TalpaertCampbell W Gourlay
Apr 22, 2015·Photodiagnosis and Photodynamic Therapy·Nasim KashefGholamreza Esmaeeli Djavid
Jun 17, 2015·BioMed Research International·Hideo YonezawaShigeru Kamiya
Dec 19, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Maria D HernandezRabih O Darouiche
Apr 8, 2016·Expert Opinion on Pharmacotherapy·Concepcion Perez-JorgeJaime Esteban
May 18, 2016·Scanning·Mehmet Emin OngerSuleyman Kaplan
Oct 31, 2015·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Ayca Tuba UlusoyZafer C Cehreli
May 10, 2005·Ophthalmology·Antonio PinnaFrancesco Carta
Jul 5, 2018·Expert Review of Respiratory Medicine·Luigino CalzettaMario Cazzola
Sep 17, 2017·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Young-Suk ChoiJin-Yong Lee

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