Influence of Na+ and anions on the dimorphic transition of Candida albicans.

Microbiology
Frederick D NorthropJulia M Davies

Abstract

The effect of Na+ (Cl- or gluconate salt) on growth and dimorphic potential of the pathogenic yeast Candida albicans has been examined. Profiles of germ tube formation as a function of salt addition, pH and temperature indicated Na+ inhibition of germ tube outgrowth at high ambient pH (pH 8.0) which was exacerbated by replacement of Cl- with gluconate (as an impermeant analogue). At acidic pH (pH 5.5) and permissive temperature (37 degrees C), gluconate alone promoted the dimorphic transition. Rates of glucose-induced medium acidification and plasma membrane H(+)-ATPase activity have been measured to assess whether salt treatments could retard the cytoplasmic alkalinization known to precede germ tube formation. The precise site of Na+ action remains unclear but the anion effects may be interpreted in terms of anion-exchanger and channel activity acting to modulate cytosolic pH.

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Citations

Jun 13, 2003·Folia Microbiologica·P HermannF Rozgonyi
Dec 1, 2005·Applied Microbiology and Biotechnology·L H GrimmD C Hempel
Jul 31, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter D AustinMarinos Elia
Jul 31, 2007·Microbiology·Olga Kinclova-Zimmermannova, Hana Sychrová
Jul 27, 2001·FEMS Microbiology Letters·G T HankeJ M Davies

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