Influence of nanostructured calcium aluminate and calcium silicate on the liver: histological and unbiased stereological analysis

International Endodontic Journal
S ParašV Jokanović

Abstract

To examine the potential systemic toxicity of nanostructured materials based on calcium silicate and calcium aluminate, for potential application in Dentistry. Twenty-four Albino Wistar rats aged 2 months were used as an in vivo animal model for subcutaneous implantation of the investigated materials, placed in polyethylene tubes. Thirty days after implantation, the livers of the rats were analysed and following histological and stereological parameters were evaluated for volume density of hepatocytes and blood sinusoids, number and numerical density of hepatocytes, surface of hepatocytes and their nucleuses, nucleocytoplasmic ratio and mitotic index of hepatocytes. Stereological measurements were achieved using Cavalieri's principle, with grid P2 and unbiased analysis. Additionally, immunohistochemistry studies were performed to further analyse changes in liver tissue. Several haematological and biochemical parameters of blood of experimental animals were also analysed, as well as local tissue reactions around the implants. Statistical analysis was performed using parametric (anova and t-test) and nonparametric tests (Kruskal-Wallis and Mann-Whitney U-test) depending on data distribution. Implanted dental cements led to an inc...Continue Reading

References

Nov 1, 1991·The Journal of Cell Biology·J A SwansonP E Knapp
Aug 1, 1996·Toxicology and Applied Pharmacology·H JaeschkeR A Roth
Oct 6, 1998·Journal of Endodontics·E T KohM Torabinejad
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Selzner, P A Clavien
Dec 20, 2002·Mechanisms of Development·Nelson Fausto, Jean S Campbell
Nov 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Levan MuskhelishviliEric B Henderson
Apr 28, 2004·World Journal of Gastroenterology : WJG·Mahendrakumar Chandrasekharappa BanakarElayaraja Thygarajan
Oct 14, 2004·International Endodontic Journal·C J A SousaE A Pascon
Jan 24, 2006·Acta Odontologica Scandinavica·Alexander FranzAndreas Schedle
Apr 17, 2010·The American Journal of Pathology·Shirish ParanjpeGeorge K Michalopoulos
Sep 2, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mokhtar I YousefLaila A Abdelmegid
Mar 8, 2013·International Endodontic Journal·W A Khalil, N F Eid
Jan 21, 2014·Journal of Dentistry·Li-Na NiuFranklin R Tay
Oct 1, 2014·Journal of Endodontics·Lucas da Fonseca Roberti GarciaCarlos Alberto de Souza Costa
Oct 6, 2015·Journal of Investigative and Clinical Dentistry·Alaa E DawoodDavid J Manton
Jan 15, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Andreas CharidimouSeth Love
May 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ming-Hsien HuangMing-You Shie
Jan 20, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Clare PridansDavid A Hume

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Citations

Jan 26, 2021·International Endodontic Journal·V NagendrababuP M H Dummer

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