Influence of narcotics on luminance and frequency modulated visual evoked potentials in rats.

Documenta Ophthalmologica. Advances in Ophthalmology
T JehleW A Lagrèze

Abstract

Quantification of visual function is essential for the impact of disease models and their treatment. Recently, we introduced a chronic implant model to record visual evoked potentials (VEP) in awake Brown-Norway rats. Here, we investigated the hemispheric distribution of VEP after monocular stimulation, the chronic electrode implantation and the influence of commonly used anesthetics. Potentials were recorded by electrodes, implanted epidurally over the superior colliculus. The entire visual field of the rat was stimulated. Flicker stimuli were modulated in luminance with a modulation depth from 5 to 80% at 7.5 Hz and flashes with a modulation depth of >95% in a frequency range of 2.9-38 Hz. Recordings were constant over 9 days. When one eye was blinded, the potentials recorded from the contralateral side were not affected, while the potentials of the ipsilateral side were markedly reduced. Further, potentials of awake animals were compared with those receiving general anesthetics. For one group of rats (n = 8), we administered isoflurane by inhalation in five concentrations. Four different groups (n = 7-11) were given choralhydrate (200 and 400 mg/kg) and the combination of ketamine/xyaline (65/7 or 130/14 mg/kg, respectively)...Continue Reading

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Citations

Sep 30, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T JehleW A Lagrèze
Dec 17, 2011·Journal of Neuroscience Methods·Bill RogersTimothy Q Duong
Apr 24, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Xiaoming AnHiroshi Goto
Apr 7, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Roberto SantangeloLetizia Leocani

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