Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver

Basic & Clinical Pharmacology & Toxicology
L Pari, Muthurangam Gnanasoundari

Abstract

Naringenin is a naturally occurring citrus flavanone, which has been reported to have a wide range of pharmacological properties. The present work was carried out to evaluate the effect of naringenin on antioxidant and lipid peroxidation status in liver of oxytetracycline-intoxicated rats. Intraperitonial administration of oxytetracycline 200 mg/kg for 15 days resulted a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in liver. Oxytetracycline also caused a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in liver. Oral administration of naringenin (50 mg/kg b.w.t.) with oxytetracycline significantly decreased the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the liver. In addition, naringenin significantly increased the activ...Continue Reading

References

Sep 1, 1976·Journal of Agricultural and Food Chemistry·T HonohanR E Wingard
Feb 1, 1988·Biochemical Medicine and Metabolic Biology·A K Ratty, N P Das
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J M McCordI Fridovich
Jan 1, 1984·Biochemical Pharmacology·S PassiG Serlupi-Crescenzi
Jan 1, 1984·Methods in Enzymology·I D Desai
Mar 15, 1981·Chemico-biological Interactions·M Younes, C P Siegers
Dec 1, 1995·The American Journal of Cardiology·T G ElliottG B Mancini
Apr 1, 1994·Archives of Pharmacal Research·J S ChoiH S Young
Feb 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K F SantosM G Oliveira
May 17, 2000·FEBS Letters·F A van AckerA Bast
Jun 1, 2000·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·I F Cheng, K Breen
Feb 24, 2001·International Archives of Occupational and Environmental Health·K A KimY Chung
Apr 12, 2001·Seminars in Liver Disease·D PessayreA Mansouri
Feb 21, 2003·Free Radical Research·Lurdes MiraKeith R Jennings
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jan 8, 2004·Biological & Pharmaceutical Bulletin·Mi-Hye LeeJeon-Ok Moon
Jun 1, 1952·Archives of Biochemistry and Biophysics·B CHANCEF J W ROUGHTON
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Bradford W Gibson

❮ Previous
Next ❯

Citations

Sep 7, 2013·Environmental Toxicology and Pharmacology·Rhaul OliveiraInês Domingues
Jun 2, 2012·TheScientificWorldJournal·Somya A NassarK M Mahran
Sep 27, 2013·BioMed Research International·Somia A NassarSoad M Nasr
Aug 17, 2014·Environmental Toxicology and Pharmacology·Amr A FouadWafaey Gomaa
Feb 18, 2016·Journal of Agricultural and Food Chemistry·Sumit Kumar, Ashu Bhan Tiku
Aug 31, 2010·The Science of the Total Environment·Zhenxing ChiHao Zhang
Dec 10, 2008·Toxicology·J Renugadevi, S Milton Prabu
Jan 9, 2007·Journal of Ethnopharmacology·Sung-Hui TsengChing-Chiung Wang
Jul 15, 2015·Journal of Natural Products·Renata M MartinezRubia Casagrande
Jun 27, 2015·Environmental Science and Pollution Research International·Toshiki NakanoNorimi Nagamine
Apr 10, 2013·European Journal of Medicinal Chemistry·Aihua ZhangXijun Wang
Nov 3, 2007·Phytochemistry·Juan Carlos EspínFrancisco A Tomás-Barberán
Aug 11, 2016·Zebrafish·Giulia ChemelloIke Olivotto
Mar 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anton MisakKarol Ondrias
May 2, 2018·World Journal of Gastroenterology : WJG·Erika Hernández-Aquino, Pablo Muriel
Apr 3, 2019·Environmental Science and Pollution Research International·Sara RodriguesAlberto Teodorico Correia
Jan 14, 2021·Critical Reviews in Food Science and Nutrition·Yue WangChong-De Sun
Mar 17, 2021·Phytotherapy Research : PTR·Karim NarakiGholamreza Karimi
Feb 24, 2007·Journal of Agricultural and Food Chemistry·Juan E Andrade, John R Burgess

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.