Influence of Nasal Tear Osmolarity on Ocular Symptoms Related to Dry Eye Disease

American Journal of Ophthalmology
Ho Chul YiYoung Joo Shin

Abstract

To investigate relationships between local tear osmolarity and tear film characteristics and dry eye disease (DED) symptoms. Prospective, cross-sectional, observational study. Nasal and temporal tear osmolarity were measured in subjects with DED. The difference between nasal and temporal tears (OSM difference) was then calculated. Ocular symptoms were evaluated and tear break-up time (TBUT), corneal fluorescein staining score (CFSS), eyelid hyperemia, and tear production were measured. Correlations between DED symptoms and nasal tear osmolarity, temporal tear osmolarity, OSM difference, and tear film characteristics were evaluated using Pearson correlation analyses. Subjects were divided into 3 groups based on OSM difference: the temporal group had a temporal osmolarity > nasal osmolarity, the nasal group had a temporal osmolarity < nasal osmolarity, and the equal group had an OSM difference < 10 mOsm/L. Forty-eight eyes of 48 subjects were included. Eleven eyes were in the temporal group, 17 eyes were in the equal group, and 20 eyes were in the nasal group. Temporal osmolarity, nasal osmolarity, and OSM difference were not correlated with TBUT, CFSS, lid hyperemia, or tear production. Nasal tear osmolarity was correlated with ...Continue Reading

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Citations

Aug 18, 2020·Clinical Ophthalmology·Nina Asrini NoorTjahjono D Gondhowiardjo
Aug 28, 2021·Diagnostics·Pilar CañadasMargarita Calonge

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