Abstract
This study looked at respiratory symptoms, peak expiratory flow rates (PEFRs), airway responsiveness to methacholine and inflammatory changes on bronchial biopsies, bronchial lavage (BL), and bronchoalveolar lavage (BAL) during natural antigenic exposure in nine subjects with pollen-sensitized seasonal asthma. The subjects recorded daily symptoms of asthma, cough and rhinitis, and morning and evening PEFRs between January and September, during and out of the pollen exposure. Baseline forced expiratory volume in 1 second, forced vital capacity, and methacholine responsiveness were measured every 3 to 4 weeks. BAL, BL, and bronchial biopsies were performed in the pollen season at the initial increase of asthma symptoms and out of pollen exposure. At the time of bronchoscopy during the pollen season compared with out of season, asthmatic subjects had an increase in asthma symptom score (1.18 +/- 0.24/0.44 +/- 0.18, p < 0.05), a reduction of PEFR (407 +/- 23/442 +/- 20 L/min, p = 0.02), and a decrease in PC20 (1.15/1.48 mg/ml, p = 0.05). In asthmatic subjects, median BAL and BL cell counts and cell differentials during or out of antigenic exposure were similar, but BAL and BL eosinophils and metachromatic cells counts were always h...Continue Reading
References
Nov 1, 1990·American Journal of Respiratory Cell and Molecular Biology·C E BrewsterW R Roche
Dec 1, 1989·The American Review of Respiratory Disease·P K JefferyA B Kay
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Jul 1, 1986·Clinical Allergy·A J DorwardN C Thomson
Aug 1, 1988·The American Review of Respiratory Disease·M LavioletteR Coulombe
Dec 10, 1988·BMJ : British Medical Journal·S LozewiczR J Davies
Oct 1, 1987·The American Review of Respiratory Disease·P M O'ByrneJ G Kirby
Apr 1, 1986·Chest·W J MetzgerG W Hunninghake
Jul 1, 1987·The American Review of Respiratory Disease
Sep 1, 1985·Clinical Allergy·S R Durham, A B Kay
Mar 1, 1969·Thorax·M S DunnillJ A Anderson
Jun 1, 1983·Thorax·J R BatemanS W Clarke
Apr 1, 1982·Thorax·E F JuniperF E Hargreave
Dec 1, 1981·Chest·B FoxR Rawbone
Citations
Jul 1, 1997·Clinical Reviews in Allergy & Immunology·S A Tilles, E J Bardana
Feb 4, 2003·Current Allergy and Asthma Reports·Madeleine Ennis
Aug 25, 1995·European Journal of Pharmacology·C M HerdC P Page
Feb 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C HudonL P Boulet
Feb 13, 2001·Allergy·J MonteseirínF Sobrino
Jan 20, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J S ErjefältC G Persson
Jun 1, 1996·The Journal of Experimental Medicine·J MonteseirínF Sobrino
Nov 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A J Woolcock, G King
Sep 1, 1996·Respirology : Official Journal of the Asian Pacific Society of Respirology·N S Zhong
May 1, 1994·British Journal of Pharmacology·C M HerdC P Page
Jun 5, 2003·Postgraduate Medical Journal·R H GreenA J Wardlaw
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·E BaraldiF Zacchello
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·A JatakanonP J Barnes
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Feb 26, 2005·American Journal of Respiratory Cell and Molecular Biology·Nives ZimmermannMarc E Rothenberg
Jan 10, 2014·American Journal of Respiratory and Critical Care Medicine·Mary B RiceKent E Pinkerton
Sep 30, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shih-Ming ChenPei-Jane Tsai
Sep 3, 1998·Chest·L P BouletM Laviolette
May 8, 2013·Chest·Aaron S Bernstein, Mary B Rice
Sep 17, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J MonteseirínJ Conde
Mar 14, 2000·Respiratory Medicine·P WeinerM Weiner
Jan 31, 2003·Respiratory Medicine·M J Alvarez-PueblaJ M Olaguibel-Rivera
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·J ChakirL P Boulet
Apr 6, 2004·Immunology and Allergy Clinics of North America·Claus BachertJean Bousquet
Jun 10, 2011·International Archives of Allergy and Immunology·Makiko FukunagaChisei Ra
Sep 6, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G M GauvreauP M O'Byrne
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B D'AgostinoF Rossi
May 18, 2012·The Cochrane Database of Systematic Reviews·Bhupendrasinh F Chauhan, Francine M Ducharme
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arash Shoja SaffarAbdelilah Soussi Gounni
Oct 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M-E Boulay, L-P Boulet
Jul 10, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Alicja Kasperska-ZajacBarbara Rogala
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization