Influence of neoadjuvant chemotherapy on radiotherapy for breast cancer

Annals of Surgical Oncology
Amit K Garg, Thomas A Buchholz

Abstract

Neoadjuvant chemotherapy is a standard treatment option for patients with locally advanced operable breast cancer and is increasingly used in early breast cancer. Initial randomized trials of neoadjuvant chemotherapy established equivalency to adjuvant chemotherapy in terms of survival, but they also demonstrated improved rates of breast conservation and the ability to modify the risk of locoregional recurrence after a favorable response to chemotherapy. High-quality nonrandomized data have helped to tailor radiotherapy treatment recommendations after neoadjuvant chemotherapy and breast-conserving surgery or mastectomy. Results from an ongoing phase 3 randomized trial (NSABP B-51/RTOG 1304) will help to clarify the value of locoregional radiotherapy for patients with clinical N1 disease that becomes node negative after neoadjuvant chemotherapy.

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Citations

Mar 3, 2015·Annals of Surgical Oncology·Judy C Boughey, Kelly K Hunt
Apr 26, 2019·Annals of Surgical Oncology·Harry D Bear, Kandace P McGuire
Dec 12, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Kennya Medeiros L de B LimaGustavo Nader Marta

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