Influence of neoadjuvant chemotherapy on prognosis of patients with synovial sarcoma

World Journal of Surgical Oncology
Yanan WuMeng Xu

Abstract

This study aimed to explore the clinical efficacy of neoadjuvant chemotherapy combined with surgery in primary synovial sarcoma of the limbs and trunk through retrospective analysis of patients with primary synovial sarcoma of the limbs and trunk treated by this treatment in our hospital. A total of 89 patients diagnosed with synovial sarcoma were enrolled in this study between January 2005 and December 2011 in PLA General Hospital. Most of the patients received neoadjuvant chemotherapy combined with operative treatment (84.3%), 10.1% of them received adjuvant chemotherapy combined with operative treatment, and only 5.6% received merely operative treatment. The influence on the prognosis of patients with synovial sarcoma was analyzed by the statistics overall survival (OS), progression-free survival (PFS), local control (LC), and freedom from distant metastasis (FFDM). The median follow-up time was 68.6 months. The 5-year OS, 5-year PFS, 5-year LC, and 5-year FFDM of the patients were 80.2, 60.5, 78.8, and 80.8%, respectively. The OS of the patients with a tumor size >5 cm was lower (91.4 vs 73.1%, P < 0.05). Besides, the OS and FFDM of neoadjuvant chemotherapy were better than those of adjuvant chemotherapy (84.5 vs 55.6%, P =...Continue Reading

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Citations

Dec 2, 2017·Journal of Surgical Oncology·Anastasia Constantinidou, Robin L Jones
Aug 15, 2018·World Journal of Surgical Oncology·Ziyad M MohaidatIbrahim R Yousef
Dec 4, 2019·Clinical Case Reports·Sara HalilyFarida Marnissi
Mar 24, 2021·Oncology Research and Treatment·Anastasios KyriazoglouPatrick Schöffski
Jan 1, 2022·The Bone & Joint Journal·Laura J HartleyScott Evans

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Methods Mentioned

BETA
surgical resection
biopsy
amputation

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