Influence of neutrophil-lymphocyte ratio in prognosis of glioblastoma multiforme

Journal of Neuro-oncology
Marta LopesPaulo Linhares

Abstract

Neutrophil-lymphocyte ratio (NLR) is a hematological marker of systemic inflammation and several studies demonstrate an association between a higher NLR and a worse prognosis in many malignancies. However, literature analyzing its prognostic value in glioblastoma multiforme (GBM) is still scarce. We intended to analyze the correlation of NLR with overall survival and progression-free survival in patients with GBM performing a retrospective review of the patients with diagnosis of GBM submitted to a resection surgery in the department of neurosurgery of a tertiary care hospital, between January/2005 and January/2013. 140 patients were included. Mean age at surgery was 62.9 ± 10.0 years and mean age at death was 64.4 ± 9.8 years. Mean overall survival was 19.4 ± 14.3 months and mean progression-free survival was 9.4 ± 8.7 months. There was no correlation of NLR, platelets-lymphocyte ratio (PLR) or absolute counts of neutrophils, lymphocytes and platelets with overall survival in multivariate analysis. However, a preoperative NLR ≤ 5 correlated with a shorter progression-free survival [HR 1.56 (SD 95% 1.04-2.34); p = 0.032]. We performed a subgroup analysis of patients who completed Stupp protocol. In this subgroup of 117 patients...Continue Reading

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Citations

Sep 2, 2019·World Journal of Surgical Oncology·Yu-Ying LeiAi-Xia Sui
Sep 29, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Guzin Ozden, Didar Yanardag Acik
Apr 25, 2019·Cancers·Sascha MarxBernhard H Rauch
May 23, 2019·Frontiers in Oncology·Michal YalonRuty Mehrian-Shai
Aug 30, 2018·Frontiers in Pharmacology·Peng-Fei WangChang-Xiang Yan
Apr 15, 2019·Journal of Neuro-oncology·Woo Jin KimChul-Kee Park
Aug 23, 2020·International Journal of Molecular Sciences·Paulo LinharesBruno M Costa
Nov 17, 2019·CNS Neuroscience & Therapeutics·Paulo LinharesRui Vaz
Mar 7, 2021·Medical Sciences : Open Access Journal·Richard E Kast
Jun 22, 2021·Frontiers in Oncology·Hamza AliMyron G Best

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