Influence of nitric oxide synthase inhibition on the development of rapid tolerance to ethanol

Brain Research Bulletin
J M KhannaG Shah

Abstract

We recently reported that the nitric oxide (NO) synthase inhibitor L-nitroarginine (L-NA) blocks the development of rapid tolerance to the motor incoordinating effect of ethanol in the tilt-plane test. To clarify the mechanism of L-NA blockade of tolerance, four additional experiments were carried out using the same test. The first demonstrated that L-NA prevented the development of rapid tolerance to ethanol when injected prior to ethanol either on both Days 1 and 2 or only on Day 1. In the second experiment, tolerance was blocked only when L-NA was injected before but not after behavioral testing on Day 1. In the third, L-NA blocked the enhancement of rapid tolerance to ethanol induced by D-cycloserine (CS), an agonist at the N-methyl-D-aspartate (NMDA) receptor. In the last experiment, L-NA pretreatment did not influence blood ethanol disappearance curves on Day 1, or ethanol concentrations in brain, tail blood or decapitated trunk blood on Day 2. These data argue against state-dependent learning as the basis of the L-NA effect, and confirm and extent our previous observation that NO plays a role in the development of rapid tolerance to ethanol.

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Citations

May 21, 2005·Alcohol·Xin-Sheng DengRichard A Deitrich
Nov 5, 2005·Brain Research. Brain Research Reviews·Randall L Davis, Peter J Syapin
May 18, 1999·Life Sciences·M IkedaS Murota
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·F Lallemand, P De Witte
May 26, 1999·Pharmacology, Biochemistry, and Behavior·J O CampbellL P Spear
Feb 19, 2002·Brain Research Bulletin·Elisabeth Wazlawik, Gina S Morato
Jul 17, 1998·Alcohol·M L Adams, T J Cicero
Jan 12, 2000·Alcoholism, Clinical and Experimental Research·V M FerreiraG S Morato
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·M H Caron, C Alling
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·J C Crabbe
Feb 26, 2021·Pharmacology, Biochemistry, and Behavior·Sophie K ElvigLeandro F Vendruscolo

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