PMID: 9436524Jan 1, 1997Paper

Influence of non-nutrient plant components on biotransformation enzymes

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
P J van Bladeren

Abstract

Plant foods contain numerous non-nutritive substances which exert biological activity. Most attention has been focused on the anticarcinogenic effects of these compounds. Many of the mechanisms involved include induction or inhibition of biotransformation enzymes. Each individual has its own isoenzyme pattern for the various drug-metabolizing enzymes. The multiplicity of these enzymes results in differential responses to dietary constituents. A substance may increase the level of a certain P450, and decrease the level of another. Although this complicates matters considerably, it also offers the possibility of specifically influencing biotransformation directed at a particular compound, e.g., a cytostatic agent. Using the important class of the glutathione S-transferase (GST) as an example, the various phenotypic and genetic origins of interindividual variation are described. Genetic variation is especially important for the mu and thetra class enzymes. The induction of individual isoenzymes of the GST has been studied in man rat. It was shown that the changes in the GST isoenzyme pattern induced by Brussels sprouts in rat liver and intestine were very similar to that caused by administration of ally isothiocyanate, and not to ...Continue Reading

References

Aug 1, 1978·Bulletin of Environmental Contamination and Toxicology·A P KulkarniE Hodgson
Jan 6, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F P Guengerich
Jul 1, 1991·Chemical Research in Toxicology·F P Guengerich, T Shimada
Jan 1, 1990·Chemico-biological Interactions·R M Vos, P J Van Bladeren
Feb 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J J BogaardsP J van Bladeren
Aug 1, 1990·The Biochemical Journal·B van OmmenP J van Bladeren
Jan 1, 1988·CRC Critical Reviews in Biochemistry·B Mannervik, U H Danielson
Feb 1, 1988·Archives of Biochemistry and Biophysics·M UjiharaO Hayaishi
Jul 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J H PloemenP J van Bladeren
Jan 5, 1996·Chemico-biological Interactions·C J RompelbergP J van Bladeren

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Citations

Jul 23, 1999·Mutation Research·M L van IerselP J van Bladeren
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Jul 10, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vlastimil MasekEva Anzenbacherova

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