Influence of non-REM sleep on inspiratory muscle activity and lung volume in asthmatic patients

The American Review of Respiratory Disease
R D BallardD P White

Abstract

To determine the effect of non-REM (NREM) sleep on inspiratory muscle electromyographic (EMG) activity in asthmatic patients and the subsequent effect of such changes on FRC, 12 asthmatic patients with nocturnal worsening were monitored overnight in a horizontal volume-displacement body plethysmograph. During studies FRC was monitored using the single inspiratory occlusion technique, whereas EMG activities of the diaphragm (DI), intercostal (IC), and sternocleidomastoid (SCM) muscles were monitored using surface electrodes. FRC decreased progressively, from 3.63 +/- 0.27 L while awake prior to "lights out" to 3.15 +/- 0.27 L after 60 min of NREM sleep (p < 0.005). With awakening at the end of the study FRC increased to 4.69 +/- 0.48 L (p < 0.01). Onset of NREM sleep was also associated with significant (p < 0.05) reductions in EMG tonic activities of all three inspiratory muscles. These levels of tonic activity returned and were further augmented (p < 0.001) with awakening at the conclusion of the study. Linear relationships were demonstrated between sleep-state dependent changes in FRC and EMG tonic activity for each of the three inspiratory muscles (r = 0.98, 0.93, and 0.97 for DI, IC, and SCM, respectively, p < 0.01). NREM s...Continue Reading

References

Oct 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K TusiewiczM H Bryan
Jan 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D GrossP T Macklem
Aug 1, 1990·Journal of Applied Physiology·R D BallardR J Martin
May 1, 1990·Journal of Applied Physiology·R D BallardD P White
Jul 1, 1989·Journal of Applied Physiology·R D BallardR J Martin
Feb 1, 1989·The American Review of Respiratory Disease·T X JiangM Decramer
Feb 1, 1988·The American Review of Respiratory Disease·K J DesmondA L Coates
Oct 1, 1987·Journal of Applied Physiology·M DecramerM Demedts
Apr 1, 1986·Journal of Applied Physiology·S C Gandevia, D K McKenzie
Sep 1, 1983·The American Review of Respiratory Disease·J G MartinL A Engel
Dec 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W S Druz, J T Sharp
Feb 1, 1984·The American Review of Respiratory Disease
Jan 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D O Rodenstein, D C Stănescu
Mar 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J M LopesA C Bryan
Mar 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M G Sampson, A De Troyer
Feb 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N L MullerN Zamel
Sep 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E TabachnikH Levison
Mar 1, 1980·The American Review of Respiratory Disease·J MartinL A Engel
Jun 1, 1952·The Journal of Physiology·E J M CAMPBELL

Citations

May 26, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·H KiyokawaK Toyama
Aug 27, 2014·Clinics in Chest Medicine·Wajahat H KhanC M D'Ambrosio
May 6, 2015·Pediatric Pulmonology·Alexandrine LaroucheGuillaume Emeriaud
Apr 29, 1998·Clinics in Chest Medicine·C M D'Ambrosio, V Mohsenin
Jun 30, 2015·Critical Care Clinics·Scott A Sands, Robert L Owens
Jan 16, 2007·Chest·Jonas AppelbergGöran Hedenstierna
Oct 8, 1999·Chronobiology International·R D Ballard

Related Concepts

Asthma
Respiratory Diaphragm
Surface Electromyography
Functional Residual Capacity
Structure of Intercostal Muscle
Lung Volume Measurements
Skeletal Muscle Structure of Neck
Respiratory Muscles
Sleep Stages

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