Influence of noncompliance with radiation therapy protocol guidelines and operative bed recurrences for children with rhabdomyosarcoma and microscopic residual disease: a report from the Children's Oncology Group.

International Journal of Radiation Oncology, Biology, Physics
Lynn MillionSoft Tissue Sarcoma Committee of the Children's Oncology Group

Abstract

Postoperative radiation therapy (RT) is recommended for patients with rhabdomyosarcoma having microscopic disease. Sometimes RT dose/volume is reduced or omitted in an attempt to avoid late effects, particularly in young children. We reviewed operative bed recurrences to determine if noncompliance with RT protocol guidelines influenced local-regional control. All operative bed recurrences among 695 Group II rhabdomyosarcoma patients in Intergroup Rhabdomyosarcoma Study Group (IRS) I through IV were reviewed for deviation from RT protocol. Major/minor dose deviation was defined as >10% or 6-10% of the prescribed dose (40-60 Gy), respectively. Major/minor volume deviation was defined as tumor excluded from the RT field or treatment volume not covered by the specified margin (preoperative tumor volume and 2- to 5-cm margin), respectively. No RT was a major deviation. Forty-six of 83 (55%) patients with operative bed recurrences did not receive the intended RT (39 major and 7 minor deviations). RT omission was the most frequent RT protocol deviation (19/46, 41%), followed by dose (17/46, 37%), volume (9/46, 20%), and dose and volume deviation (1/46, 2%). Only 7 operative bed recurrences occurred in IRS IV (5% local-regional failure...Continue Reading

References

Jan 15, 1988·Cancer·H M MaurerJ Ortega
Mar 1, 1993·Cancer·H M MaurerJ Herrmann
May 17, 2005·Cancer·Stefano MazzoleniUNKNOWN Associazione Italiana di Ematologia e Oncologia Pediatrica Soft Tissue Sarcoma Committee
Aug 13, 2009·The Cancer Journal·Thomas E Merchant

❮ Previous
Next ❯

Citations

Apr 26, 2012·Current Oncology Reports·Susan L McGovern, Anita Mahajan
Mar 8, 2013·Journal of the National Cancer Institute·Nitin OhriTimothy N Showalter
Dec 20, 2011·Seminars in Radiation Oncology·Thomas J FitzGerald
Dec 12, 2013·Current Opinion in Pediatrics·Douglas S HawkinsErin R Rudzinski
Mar 22, 2018·British Journal of Nursing : BJN·Úna KerinKaren Cooke
Dec 21, 2012·Pediatric Blood & Cancer·Douglas S HawkinsUNKNOWN COG Soft Tissue Sarcoma Committee
Aug 4, 2015·Nature Genetics·Folefac AminkengUNKNOWN Canadian Pharmacogenomics Network for Drug Safety Consortium
Sep 15, 2017·Pediatric Blood & Cancer·Scott C BorinsteinLars M Wagner
Jul 28, 2020·Journal of Medical Imaging and Radiation Oncology·Laura MurphyVerity Ahern
Feb 16, 2021·Clinics in Perinatology·Tooba RashidMichael D Deel
Jul 18, 2020·Journal of Pediatric Surgery·Daniel S RheeUNKNOWN American Pediatric Surgical Association Cancer Committee
Apr 6, 2021·Pediatric Blood & Cancer·Raphael L YechieliSarah S Donaldson
Nov 30, 2021·Pediatric Blood & Cancer·Rashi AgrawalRamandeep Singh Arora

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Lester J PetersDanny Rischin
International Journal of Radiation Oncology, Biology, Physics
T J FitzgeraldNancy Rosen
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P PoortmansWalter Van den Bogaert
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Elena MusatLaurence Collette
© 2021 Meta ULC. All rights reserved