Influence of NRGN rs12807809 polymorphism on symptom severity in individuals with schizophrenia in the Han population but not the Zhuang population of south China

Acta Neuropsychiatrica
Li SuBo Wei

Abstract

NRGN is one of the most promising candidate genes for schizophrenia based on function and position. Therefore, this study aimed to examine the genetic association of this polymorphism with schizophrenia in the Zhuang and Han populations of south China. Subjects and methods A total of 282 patients (188 Han and 94 Zhuang) and 282 healthy subjects (188 Han and 94 Zhuang) were recruited. Of these, 246 schizophrenia patients underwent an assessment of psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS). A TaqMan genotyping assay method was used to determine the genotypes. We did not find a significant association of rs12807809 polymorphism with schizophrenia in the total pooled samples, or in the separate ethnic groups. However, in Han schizophrenia patients, quantitative data analyses showed that the CC genotype of the rs12807809 polymorphism was associated with PANSS aggression subscale score and activation subscale score. Furthermore, carriers of the C allele of rs12807809 polymorphism among Han schizophrenia patients had higher scores of general, activation, depression, aggression, and global symptoms than the T allele carriers. In conclusion rs12807809 polymorphism may not contribute to the risk of schizop...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Feb 1, 1995·Schizophrenia Research·J P LindenmayerR B Hyman
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kuo-Ping HuangDetlef Balschun
May 27, 2005·PLoS Medicine·Sukanta SahaJohn McGrath
Dec 2, 2005·Schizophrenia Bulletin·Nick CraddockMichael J Owen
Dec 5, 2006·Journal of Psychiatric Research·Dina RuanoJoana A Palha
Mar 26, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jingchun SunZhongming Zhao
Apr 11, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Hsin-An ChangSan-Yuan Huang
Jul 3, 2009·Nature·Hreinn StefanssonDavid A Collier
Jan 12, 2010·Neuroscience and Biobehavioral Reviews·Suat Ying Tan CherlynKang Sim
Apr 28, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dong Hao ZhouXiang Yang Zhang
Jul 6, 2010·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Yu-hui SunQi Xu
Apr 21, 2011·Schizophrenia Bulletin·Yunjung KimPatrick F Sullivan
Jul 30, 2011·Schizophrenia Bulletin·Axel KrugTilo Kircher
Feb 7, 2012·Schizophrenia Research·Yu-Chih ShenChia-Hsiang Chen
Mar 31, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kazutaka OhiMasatoshi Takeda

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