Influence of O and K antigens on the surface properties of Escherichia coli in relation to phagocytosis

Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
O StendahlL Edebo

Abstract

Strains of Escherichia coli with different O and K antigens were investigated with respect to physicochemical surface characteristics and liability to phagocytosis. Using two-phase partitioning analysis for the surface characterization, three main groups of strains emerged: Group I (O1:K1, O2:K1, O3:K2ab) showing both smooth hydrophilic O antigens and negatively-charged K antigen which rendered the strains maximally resistant to phagocytosis. Group II (O55:K59, O111:K58) showed no acidic K antigen but only smooth hydrophilic O antigen properties. However, these strains were as resistant to phagocytosis as the strains in group I. A third group (O14:K7, O24:K +) contained strains with rough, hydrophobic O antigen and negatively-charged K antigen. When the K antigen was removed by heat treatment these strains became more sensitive to phagocytosis. Certain other strains (O28:K-, O56:K + and O118:K-) did not fit into the three groups. These experiments show that the physicochemical surface effects and biological significance of the K antigen must be evaluated in relation to the properties conveyed by the corresponding O antigens.

References

Sep 1, 1977·Bacteriological Reviews·I OrskovK Jann
Dec 1, 1976·The Journal of Pediatrics·B BjörksténP G Quie
Jan 1, 1975·The Journal of Infectious Diseases·W R McCabeA Greely
Jun 1, 1973·The Journal of Infectious Diseases·B Kaijser
Sep 1, 1968·The Journal of Experimental Medicine·D N MedearisE C Heath
Jan 1, 1965·Acta Pathologica Et Microbiologica Scandinavica·L EDEBO, T HOLME
Sep 1, 1970·Infection and Immunity·D Friedberg, M Shilo

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