Influence of O side chains on the attachment of the Felix O-1 bacteriophage to Salmonella bacteria.

Journal of Bacteriology
A A Lindberg, T Holme

Abstract

The adsorption rate constant (ARC) of the Felix O-1 (FO) bacteriophage to sensitive Salmonella strains was used to determine the effect of variations in surface antigens on phage attachment. The N-acetylglucosamine of the common-core polysaccharide of the Salmonella lipopolysaccharide (LPS) was found to be an essential part of the receptor for the FO phage in conformation with earlier reports. It was found that (i) the ARC was low for strains having O side chains containing two or three non core monosaccharides, (ii) the ARC varied when the O side chain contained no, or only one, noncore monosaccharide, (iii) the ARC was high when the O side chain contained only one repeating unit, and (iv) the ARC was high to mutants of chemotype Ra in which the N-acetylglucosamine was the terminal sugar of the LPS. Since a good correlation was found between the ARC of the FO phage and the phage-inactivating capacity of phenol water-extracted LPS, the results suggest that only the structure and composition of the LPS determines the adsorption rate of the FO phage. The phage-inactivating capacity of LPS from the Ra mutants increased in parallel with higher glucosamine contents in the core polysaccharide. In smooth strains having long and numero...Continue Reading

References

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Citations

Sep 1, 1992·Journal of Dairy Science·F E el-Gazzar, E H Marth
Feb 3, 2009·Applied and Environmental Microbiology·Susan M LehmanAntonet M Svircev
Apr 20, 2018·Viruses·Zachary D MoyeAlexander Sulakvelidze
May 2, 2002·International Journal of Food Microbiology·Jonathan KuhnShimon Ulitzur
Nov 1, 1983·Applied and Environmental Microbiology·D C Hirsh, L D Martin
Oct 1, 1974·Journal of Virology·F J Castillo, P F Bartell
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Mar 1, 1971·Journal of Bacteriology·A Wright, N Barzilai
Sep 1, 1993·Microbiological Reviews·C A Schnaitman, J D Klena

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