PMID: 6360432Dec 1, 1983

Influence of obesity on basal glucagon levels in non-diabetic and diabetic Nauruans

Clinical Endocrinology
F P AlfordS Whitehouse

Abstract

Basal plasma glucagon (IRG), insulin (IRI) and glucose levels were measured in normal weight (Body Mass Index (BMI) less than 30) and obese (BMI greater than or equal to 30) non-diabetic and diabetic Micronesians (n = 30) on Nauru Island. This population has a high prevalence of diabetes mellitus. IRG levels were significantly higher (P less than 0.02) in the non-diabetic obese, compared to the non-diabetic lean subjects (109 +/- 19 vs 44 +/- 12 SEM pg/ml, respectively) and there was a significant positive correlation between basal IRG and BMI (r = 0.79, P less than 0.001). IRG levels were similar in diabetic obese and diabetic lean subjects. The pathophysiological significance of the hyperglucagonaemia in these obese subjects is not known, although it may be related to the frequent development of diabetes in this unique population.

References

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Citations

Jun 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·P HillF de Waard
Aug 8, 2009·The Journal of Clinical Investigation·Eric D BerglundDavid H Wasserman
Jun 16, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Lusha XiangRobert L Hester

Related Concepts

Diabetes Mellitus
Glucagon
Novolin
Obesity

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