Influence of oestrogen deficiency on the development of apical periodontitis

International Endodontic Journal
S C BrasilL Armada

Abstract

To evaluate the effects of a long period of oestrogen deficiency on the development of apical periodontitis in rats. Wistar rats (n = 24), 3 months old, evaluated by vaginal cytology, were included in the study. Twelve animals were ovariectomized (OVX group) and the other 12 were sham operated (control group). One hundred and twenty days after castration, the pulps of the left mandibular first molars were exposed to induce the development of apical periodontitis. Body mass was verified on a weekly basis. Following 21 and 40 days of lesion induction, the animals were sacrificed. Blood was collected for biochemical analysis, and mandibles were removed for radiographic analysis. Comparative analysis of the data was performed by the nonparametric Kruskal-Wallis and Dunn's multiple-comparisons tests. The t-test was applied to compare the oestrogen levels between control and OVX groups. Radiographs revealed that apical periodontitis lesions were significantly larger in the 40-day OVX group when compared with both 40-day (P < 0.05) and 21-day (P < 0.001) control groups. Serum oestrogen levels were significantly lower in the OVX group (P < 0.01), confirming the efficacy of castration. Oestrogen deficiency resulted in significantly grea...Continue Reading

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Citations

Feb 9, 2019·International Endodontic Journal·S ChenX Huang
Mar 12, 2020·Brazilian Dental Journal·Alice Corrêa Silva-SousaErika Calvano Küchler
Nov 30, 2019·International Journal of Dentistry·Supanee ThanakunYuichi Izumi
Jan 3, 2021·Journal of Endodontics·Sabrina C BrasilLuciana Armada
Nov 15, 2020·Clinical Oral Investigations·Marília Pacífico LucisanoLea Assed Bezerra da Silva
Jun 9, 2021·Cell Proliferation·Leming JiaXin Xu
Nov 19, 2020·Life Sciences·Camilla Dos Santos Tibúrcio-MachadoCarlos Alexandre Souza Bier

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