Influence of olfactory bulbectomy on maternal behavior and dopaminergic function in nucleus accumbens in mice

Behavioural Brain Research
Atsushi SatoTakeshi Tadano

Abstract

Olfactory bulbectomy (OBX) induces behavioral, physiological, and neurochemical alterations resembling clinical depression and is widely used as an animal model of depression. It has been reported that depression is a critical cause of child abuse and neglect and that maternal behavior involves dopaminergic neurons of the mesolimbic pathway. In a previous study we found that OBX mice show maternal behavior deficits which are improved by administration of apomorphine, a non-selective dopamine agonist. Therefore, in this study, we investigated the effect of l-3,4-dihydroxyphenylalanine (l-DOPA) on maternal behavior deficits to examine the influence of pre-synaptic dopaminergic function in OBX mice. Furthermore, we measured tyrosine hydroxylase (TH) levels using microphotometry and quantified dopamine D1- and D2-like receptors using autoradiography in the nucleus accumbens (NAc). As a result, 25mg/kg l-DOPA with 12.5mg/kg benserazide improved disrupted maternal behavior in OBX mice and there are no changes in TH levels or number of D1- and D2-like receptors between sham and OBX mothers. The behavioral data support the hypothesis that changed dopaminergic function may contribute to maternal behavior deficits in OBX mice. However, o...Continue Reading

References

Jun 15, 1991·Biological Psychiatry·W J Giardina, R J Radek
May 8, 1985·European Journal of Pharmacology·J R Ieni, J B Thurmond
Feb 1, 1973·Physiology & Behavior·J G Vandenbergh
Aug 1, 1973·Journal of Comparative and Physiological Psychology·B M ThorneE E Latham
Mar 1, 1972·Journal of Reproduction and Fertility·R GandelmanV H Denenberg
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·S M Jancsàr, B E Leonard
Mar 1, 1980·Physiology & Behavior·J L Tyler, R A Gorski
Oct 1, 1995·Pharmacopsychiatry·B OlivierR Hen
Apr 1, 1996·Physiology & Behavior·D J CalcagnettiM D Schechter
Dec 5, 1997·The Journal of Comparative Neurology·P J ShughrueI Merchenthaler
Feb 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A MarkouG F Koob
Sep 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T ArakiY Itoyama
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·H S StockM A Wilson
Jun 28, 2003·Pharmacology & Toxicology·Maria Rita P SilvaLuciano F Felicio
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·Conan Kornetsky
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frances A ChampagneMichael J Meaney
Jan 13, 2005·Neuroscience Letters·M ZuegerP Gass
Apr 7, 2005·Physiology & Behavior·Yael Lavi-AvnonAron Weller
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Cai Song, Brian E Leonard
Jul 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven L BealerWilliam R Crowley

❮ Previous
Next ❯

Citations

Feb 9, 2013·Bioscience, Biotechnology, and Biochemistry·Ryoo TaniguchiTakeshi Tadano
Nov 7, 2013·The European Journal of Neuroscience·Claudia PudellAnete C Ferraz
Oct 8, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jana Ruda-KucerovaMagdalena Sustkova-Fiserova
Feb 23, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kumi O KurodaMichael Numan
Jul 20, 2014·Hormones and Behavior·Rebeca Corona, Frédéric Lévy
Sep 13, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Amal AlachkarOlivier Civelli
Oct 11, 2011·Developmental Cognitive Neuroscience·Ilanit GordonJames F Leckman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.