Influence of Omalizumab on Allergen-Specific IgE in Patients with Adult Asthma

International Archives of Allergy and Immunology
Hiroko MizumaHironori Sagara

Abstract

Omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, inhibits the binding of circulating IgE to mast cells and basophils, resulting in fewer episodes of airway inflammation, asthma symptoms and exacerbations in patients with severe allergic asthma. Treatment of patients with asthma using omalizumab increases serum total IgE (tIgE) levels. However, little is known about the influence of omalizumab on allergen-specific IgE (sIgE). tIgE and sIgE in 47 adult patients with severe asthma were measured with a fluorescent enzyme immunoassay (ImmunoCAP-FEIA) before and after omalizumab treatment. Treatment with omalizumab increased tIgE and sIgE levels. The increases in sIgE by class category after omalizumab treatment were positively correlated with baseline sIgE positivity before treatment. The mean changes in sIgE levels after omalizumab treatment were also correlated with baseline sIgE levels before treatment. The mean changes in tIgE levels were positively correlated with the mean changes in IgE levels against Dermatophagoides pteronyssinus, crude house dust, Japanese cedar and moth. Omalizumab markedly influenced the negative-to-positive seroconversion rate for IgE against Japanese cedar (30.8%), Candida (29.0%) and mot...Continue Reading

Citations

Aug 16, 2017·Journal of Clinical Laboratory Analysis·Zhanhu ZhangHaibo Li
Dec 7, 2018·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali Komi, Leif Bjermer
May 26, 2018·Clinical and Molecular Allergy : CMA·Sonali J BrackenAdam P Matson
Dec 18, 2019·Parasites & Vectors·Ran HeGuang-You Yang
Mar 19, 2021·Expert Opinion on Biological Therapy·Stefano PassanisiGiovanni B Pajno
Jan 18, 2020·The Journal of Allergy and Clinical Immunology. in Practice·J Andrew BirdAnna Nowak-Wegrzyn

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