Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study

Journal of the American College of Cardiology
Martine GilardJacques Boschat

Abstract

This trial sought to assess the influence of omeprazole on clopidogrel efficacy. Clopidogrel has proved its benefit in the treatment of atherothrombotic diseases. In a previous observational study, we found clopidogrel activity on platelets, tested by vasodilator-stimulated phosphoprotein (VASP) phosphorylation, to be diminished in patients receiving proton pump inhibitor (PPI) treatment. In this double-blind placebo-controlled trial, all consecutive patients undergoing coronary artery stent implantation received aspirin (75 mg/day) and clopidogrel (loading dose, followed by 75 mg/day) and were randomized to receive either associated omeprazole (20 mg/day) or placebo for 7 days. Clopidogrel effect was tested on days 1 and 7 in both groups by measuring platelet phosphorylated-VASP expressed as a platelet reactivity index (PRI). Our main end point compared PRI value at the 7-day treatment period in the 2 groups. Data for 124 patients were analyzed. On day 1, mean PRI was 83.2% (standard deviation [SD] 5.6) and 83.9% (SD 4.6), respectively, in the placebo and omeprazole groups (p = NS), and on day 7, 39.8% (SD 15.4) and 51.4% (SD 16.4), respectively (p < 0.0001). Omeprazole significantly decreased clopidogrel inhibitory effect on ...Continue Reading

References

Sep 24, 1999·Alimentary Pharmacology & Therapeutics·T Ishizaki, Y Horai
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Sep 25, 2002·Journal of Internal Medicine·P JäremoA Richter
Nov 19, 2002·JAMA : the Journal of the American Medical Association·Steven R SteinhublUNKNOWN CREDO Investigators. Clopidogrel for the Reduction of Events During Observation
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomas A Clarke, Lucy A Waskell
Jun 25, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Paul BarraganMartin Eigenthaler
Aug 20, 2003·Circulation·Jacqueline SawUNKNOWN Clopidogrel for the Reduction of Events During Observation Investigators
Apr 9, 2005·Clinical Chemistry·Jörg GeigerReinhard Schinzel

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Citations

Oct 30, 2008·European Journal of Clinical Pharmacology·Ulrich Klotz
Jun 19, 2012·European Journal of Clinical Pharmacology·Jia WuJian-Ting Cai
Feb 15, 2013·Cardiovascular and Interventional Radiology·Georgios PastromasDimitrios Siablis
Oct 14, 2009·Wiener medizinische Wochenschrift·Angela Storka, Johannes Pleiner
Oct 3, 2008·Journal of Thrombosis and Thrombolysis·Qian-Ping GaoLu Fu
Feb 17, 2010·Journal of Thrombosis and Thrombolysis·Gianluca CampoRoberto Ferrari
May 9, 2012·Journal of Thrombosis and Thrombolysis·S Michael GharacholouAmish N Raval
Sep 19, 2009·Irish Journal of Medical Science·D MolloyM Hennessy
Nov 22, 2011·Current Atherosclerosis Reports·Luke KimDmitriy N Feldman
Oct 22, 2013·Current Atherosclerosis Reports·Kiran KalraPaul A Gurbel
May 23, 2013·Current Gastroenterology Reports·Lauren B Gerson
Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Fernando D Testai, Philip B Gorelick
Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Carlos G Santos-GallegoJuan José Badimón
Dec 8, 2010·Current Treatment Options in Cardiovascular Medicine·Matthew W SherwoodRichard C Becker
Dec 21, 2011·Current Treatment Options in Cardiovascular Medicine·Mark R Thomas, Robert F Storey
Jul 13, 2011·Neurocritical Care·Clemens M SchirmerAnish Bhardwaj
Nov 8, 2011·Journal of Cardiovascular Translational Research·Mathieu PankertThomas Cuisset
Jan 15, 2013·Journal of Cardiovascular Translational Research·Thomas Cuisset, Jacques Quilici
May 26, 2009·JACC. Cardiovascular Interventions·Neal S Kleiman
Feb 6, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Seth R SchwartzMilesh M Patel
Apr 9, 2009·Nature Reviews. Cardiology·Joseph M SweenyValentin Fuster
May 28, 2009·Nature Reviews. Cardiology·José Luis Ferreiro, Dominick J Angiolillo
Feb 2, 2010·Nature Reviews. Drug Discovery·Alan D Michelson
Jun 8, 2011·Nature Reviews. Gastroenterology & Hepatology·Carlos Sostres, Angel Lanas
Jan 24, 2009·The New England Journal of Medicine·Jane E Freedman, Elaine M Hylek
Sep 1, 2009·The New England Journal of Medicine·Albert Schömig
Dec 25, 2008·The New England Journal of Medicine·Tabassome SimonUNKNOWN French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
Oct 12, 2010·The New England Journal of Medicine·Deepak L BhattUNKNOWN COGENT Investigators
Oct 11, 2012·Genetic Testing and Molecular Biomarkers·Qian LiuQing-Chun Zhao
Jul 30, 2009·European Heart Journal·Céline VerstuyftRichard B Kim
Feb 18, 2010·European Heart Journal·Dirk SibbingAdnan Kastrati
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Dec 7, 2010·The Journal of Antimicrobial Chemotherapy·Paul A Pham, Charles Flexner
Jun 5, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas GremmelSimon Panzer

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