Influence of oral supplementation of ascorbate upon the induction of N-methyl-N'-nitro-N-nitrosoguanidine

Cancer Letters
H KawasakiE Kimoto


Influence of mega-ascorbate (AsA) intake upon the induction of gastric cancer of rats was investigated. By feeding the ascorbate-supplemented diet, though the incidence of gastric cancer was not effectively inhibited, the infiltrative growth was significantly repressed. Mega-ascorbate intake was more beneficial in alleviating the development of gastric cancer when it was commenced after the middle of long-term experimental period (initiation of adenomatous hyperplasia but no appearance of malignant lesions) rather than from the beginning of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) drinking. A remarkable effect of mega-ascorbate intake was to reinforce the surrounding connective tissues to retard the malignant growth.


Sep 30, 1975·Annals of the New York Academy of Sciences·S S Mirvish
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J J KammJ J Burns
Jan 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·A CardesaP Shubik

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Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·R M BalanskyI Chernozemskí
Dec 1, 1995·Journal of the American College of Nutrition·M Cohen, H N Bhagavan
Aug 1, 1986·Cancer·H W Daniell
Dec 11, 1999·Carcinogenesis·C T Stadtländer, J W Waterbor
Feb 1, 1985·The Proceedings of the Nutrition Society·P Correa
Jan 1, 1985·Langenbecks Archiv für Chirurgie·B WernerH Schäfer

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