PMID: 15374207Nov 1, 1995Paper

Influence of orthostatic hypotension in Parkinson's disease on plasma atrial natriuretic peptide

Archives of Gerontology and Geriatrics
S D LennoxK Woodhouse

Abstract

The effect of orthostatic hypotension in Parkinson's disease (PD) on plasma atrial natriuretic peptide (ANP) was examined in fifteen individuals with PD without autonomic dysfunction (63-85 years), nine PD patients with autonomic dysfunction (orthostatic hypotension; systolic BP change > 20 mmHg after 5 min standing: 69-82 years) and 14 fit elderly volunteers (62-93 years). The mean ANP level was 42.2 pg/ml (range 16.8-89.2 pg/ml) in the PD group without autonomic dysfunction; 44.4 pg/ml (range 27.2-91.2 pg/ml) in the PD group with autonomic dysfunction; and 48.5 pg/ml (range 22.2-111.6 pg/ml) in the elderly group. There was no statistical difference in plasma atrial natriuretic peptide between all three groups. The mean change in blood pressure was -39 mmHg (systolic) and -18 mmHg (diastolic) between supine and standing in the group with orthostatic hypotension.

References

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Jul 1, 1991·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P FaschingH Vierhapper
Dec 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·C C Lang, A D Struthers
Jan 1, 1990·European Journal of Clinical Pharmacology·P FerrariP Weidmann
Jul 1, 1994·Archives of Gerontology and Geriatrics·S D LennoxK Woodhouse

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Citations

Aug 10, 2000·Medicinal Research Reviews·L ProkaiN Bodor

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